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Published in: Surgery Today 7/2017

01-07-2017 | Original Article

The effect of Daikenchuto on postoperative intestinal motility in patients with right-side colon cancer

Authors: Takeshi Yamada, Satoshi Matsumoto, Michihiro Koizumi Akihisa Matsuda, Seiichi Shinji, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Kouki Takeda, Keiichiro Ohta, Eiji Uchida

Published in: Surgery Today | Issue 7/2017

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Abstract

Purpose

Daikenchuto (DKT) has a stimulant effect on intestinal motility and reportedly has a positive effect on postoperative intestinal motility in patients with sigmoid colon cancer. In this study, we investigated the effects of DKT in patients with right-side colon cancer.

Methods

This retrospective study included 88 patients with right-side colon cancer. We orally administered 7.5 g of DKT in the DKT group and did not administer any DKT to patients in the no-DKT group. All patients ingested radiopaque markers 2 h before surgery, which were used to assess intestinal motility. The postoperative intestinal motility was radiologically assessed by counting the numbers of residual markers in the large and small intestines.

Results

The DKT and no-DKT groups showed no marked differences in the total number of residual markers or number of residual markers in the small intestine. However, in the elderly subgroup, the total number of residual markers in the DKT group was significantly less than in the no-DKT group.

Conclusion

Although DKT had some small effect on the postoperative intestinal motility for most patients, it may have positive effects in elderly patients.
Literature
1.
go back to reference Fearon KC, Ljungqvist O, Von Meyenfeldt M, Revhaug A, Dejong CH, Lassen K, et al. Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr (Edinburgh, Scotland). 2005;24:466–77. Fearon KC, Ljungqvist O, Von Meyenfeldt M, Revhaug A, Dejong CH, Lassen K, et al. Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr (Edinburgh, Scotland). 2005;24:466–77.
2.
go back to reference Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg. 2008;248:189–98.CrossRefPubMed Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg. 2008;248:189–98.CrossRefPubMed
3.
go back to reference Ota H, Ikenaga M, Hasegawa J, Murata K, Miyake Y, Mizushima T, et al. Safety and efficacy of an “enhanced recovery after surgery” protocol for patients undergoing colon cancer surgery: a multi-institutional controlled study. Surg Today. 2016. Ota H, Ikenaga M, Hasegawa J, Murata K, Miyake Y, Mizushima T, et al. Safety and efficacy of an “enhanced recovery after surgery” protocol for patients undergoing colon cancer surgery: a multi-institutional controlled study. Surg Today. 2016.
4.
go back to reference Sugisawa N, Tokunaga M, Makuuchi R, Miki Y, Tanizawa Y, Bando E, et al. A phase II study of an enhanced recovery after surgery protocol in gastric cancer surgery. Gastric Cancer Off J Int Gastr Cancer Assoc Japn Gast Cancer Assoc. 2015. Sugisawa N, Tokunaga M, Makuuchi R, Miki Y, Tanizawa Y, Bando E, et al. A phase II study of an enhanced recovery after surgery protocol in gastric cancer surgery. Gastric Cancer Off J Int Gastr Cancer Assoc Japn Gast Cancer Assoc. 2015.
5.
go back to reference Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA. A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg. 2007;245:867–72.CrossRefPubMedPubMedCentral Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA. A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg. 2007;245:867–72.CrossRefPubMedPubMedCentral
6.
go back to reference Mochiki E, Yanai M, Ohno T, Kuwano H. The effect of traditional Japanese medicine (Kampo) on gastrointestinal function. Surg Today. 2010;40:1105–11.CrossRefPubMed Mochiki E, Yanai M, Ohno T, Kuwano H. The effect of traditional Japanese medicine (Kampo) on gastrointestinal function. Surg Today. 2010;40:1105–11.CrossRefPubMed
7.
go back to reference Kono T, Shimada M, Yamamoto M, Kaneko A, Oomiya Y, Kubota K, et al. Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto. Front Pharmacol. 2015;6:159.CrossRefPubMedPubMedCentral Kono T, Shimada M, Yamamoto M, Kaneko A, Oomiya Y, Kubota K, et al. Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto. Front Pharmacol. 2015;6:159.CrossRefPubMedPubMedCentral
8.
go back to reference Kono T, Kanematsu T, Kitajima M. Exodus of Kampo, traditional Japanese medicine, from the complementary and alternative medicines: is it time yet? Surgery. 2009;146:837–40.CrossRefPubMed Kono T, Kanematsu T, Kitajima M. Exodus of Kampo, traditional Japanese medicine, from the complementary and alternative medicines: is it time yet? Surgery. 2009;146:837–40.CrossRefPubMed
9.
go back to reference Kono T, Kaneko A, Hira Y, Suzuki T, Chisato N, Ohtake N, et al. Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn’s disease mouse model. J Crohn’s Colitis. 2010;4:161–70.CrossRef Kono T, Kaneko A, Hira Y, Suzuki T, Chisato N, Ohtake N, et al. Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn’s disease mouse model. J Crohn’s Colitis. 2010;4:161–70.CrossRef
10.
go back to reference Katsuno H, Maeda K, Ohya M, Yoshioka K, Tsunoda A, Koda K, et al. Clinical pharmacology of daikenchuto assessed by transit analysis using radiopaque markers in patients with colon cancer undergoing open surgery: a multicenter double-blind randomized placebo-controlled study (JFMC39-0902 additional study). J Gastroenterol. 2015. Katsuno H, Maeda K, Ohya M, Yoshioka K, Tsunoda A, Koda K, et al. Clinical pharmacology of daikenchuto assessed by transit analysis using radiopaque markers in patients with colon cancer undergoing open surgery: a multicenter double-blind randomized placebo-controlled study (JFMC39-0902 additional study). J Gastroenterol. 2015.
11.
go back to reference Yaegashi M, Otsuka K, Itabashi T, Kimura T, Kato K, Fujii H, et al. Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy. Hepatogastroenterology. 2014;61:85–9.PubMed Yaegashi M, Otsuka K, Itabashi T, Kimura T, Kato K, Fujii H, et al. Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy. Hepatogastroenterology. 2014;61:85–9.PubMed
12.
go back to reference Kubota K, Ohtake N, Ohbuchi K, Mase A, Imamura S, Sudo Y, et al. Hydroxy-alpha sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9. Am J Physiol Gastrointest Liver Physiol. 2015;308:G579–90.CrossRefPubMedPubMedCentral Kubota K, Ohtake N, Ohbuchi K, Mase A, Imamura S, Sudo Y, et al. Hydroxy-alpha sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9. Am J Physiol Gastrointest Liver Physiol. 2015;308:G579–90.CrossRefPubMedPubMedCentral
13.
go back to reference Akamaru Y, Takahashi T, Nishida T, Omori T, Nishikawa K, Mikata S, et al. Effects of daikenchuto, a Japanese herb, on intestinal motility after total gastrectomy: a prospective randomized trial. J Gastroint Surg Off J Soc Surg Aliment Tract. 2015;19:467–72.CrossRef Akamaru Y, Takahashi T, Nishida T, Omori T, Nishikawa K, Mikata S, et al. Effects of daikenchuto, a Japanese herb, on intestinal motility after total gastrectomy: a prospective randomized trial. J Gastroint Surg Off J Soc Surg Aliment Tract. 2015;19:467–72.CrossRef
14.
go back to reference Yoshikawa K, Shimada M, Nishioka M, Kurita N, Iwata T, Morimoto S, et al. The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection. Surg Today. 2012;42:646–51.CrossRefPubMed Yoshikawa K, Shimada M, Nishioka M, Kurita N, Iwata T, Morimoto S, et al. The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection. Surg Today. 2012;42:646–51.CrossRefPubMed
15.
go back to reference Shimada M, Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, et al. Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001). Int J Clin Oncol. 2015;20:95–104.CrossRefPubMed Shimada M, Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, et al. Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001). Int J Clin Oncol. 2015;20:95–104.CrossRefPubMed
16.
go back to reference Kono T, Koseki T, Chiba S, Ebisawa Y, Chisato N, Iwamoto J, et al. Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1. J Surg Res. 2008;150:78–84.CrossRefPubMed Kono T, Koseki T, Chiba S, Ebisawa Y, Chisato N, Iwamoto J, et al. Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1. J Surg Res. 2008;150:78–84.CrossRefPubMed
17.
go back to reference Kono T, Kaneko A, Omiya Y, Ohbuchi K, Ohno N, Yamamoto M. Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine. Am J Physiol Gastrointest Liver Physiol. 2013;304:G428–36.CrossRefPubMed Kono T, Kaneko A, Omiya Y, Ohbuchi K, Ohno N, Yamamoto M. Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine. Am J Physiol Gastrointest Liver Physiol. 2013;304:G428–36.CrossRefPubMed
18.
go back to reference Manabe N, Camilleri M, Rao A, Wong BS, Burton D, Busciglio I, et al. Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. Am J Physiol Gastrointest Liver Physiol. 2010;298:G970–5.CrossRefPubMed Manabe N, Camilleri M, Rao A, Wong BS, Burton D, Busciglio I, et al. Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. Am J Physiol Gastrointest Liver Physiol. 2010;298:G970–5.CrossRefPubMed
19.
go back to reference Kawahara H, Yanaga K. The herbal medicine Dai-Kenchu-To directly stimulates colonic motility. Surg Today. 2009;39:175–7.CrossRefPubMed Kawahara H, Yanaga K. The herbal medicine Dai-Kenchu-To directly stimulates colonic motility. Surg Today. 2009;39:175–7.CrossRefPubMed
20.
go back to reference Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T. Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors. J Gastroenterol. 2014;49:1026–39.CrossRefPubMed Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T. Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors. J Gastroenterol. 2014;49:1026–39.CrossRefPubMed
21.
go back to reference Hayakawa T, Kase Y, Saito K, Hashimoto K, Ishige A, Komatsu Y, et al. Effects of Dai-kenchu-to on intestinal obstruction following laparotomy. Journal of smooth muscle research =. Nihon Heikatsukin Gakkai kikanshi. 1999;35:47–54.CrossRefPubMed Hayakawa T, Kase Y, Saito K, Hashimoto K, Ishige A, Komatsu Y, et al. Effects of Dai-kenchu-to on intestinal obstruction following laparotomy. Journal of smooth muscle research =. Nihon Heikatsukin Gakkai kikanshi. 1999;35:47–54.CrossRefPubMed
22.
go back to reference Yamada T, Kan H, Matsumoto S, Koizumi M, Matsuda A, Shinji S, et al. Dysmotility by mechanical bowel preparation using polyethylene glycol. J Surg Res. 2014;191:84–90.CrossRefPubMed Yamada T, Kan H, Matsumoto S, Koizumi M, Matsuda A, Shinji S, et al. Dysmotility by mechanical bowel preparation using polyethylene glycol. J Surg Res. 2014;191:84–90.CrossRefPubMed
Metadata
Title
The effect of Daikenchuto on postoperative intestinal motility in patients with right-side colon cancer
Authors
Takeshi Yamada
Satoshi Matsumoto
Michihiro Koizumi Akihisa Matsuda
Seiichi Shinji
Yasuyuki Yokoyama
Goro Takahashi
Takuma Iwai
Kouki Takeda
Keiichiro Ohta
Eiji Uchida
Publication date
01-07-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 7/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1449-7

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