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01-07-2012 | Original Article

The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection

Authors: Kozo Yoshikawa, Mitsuo Shimada, Masanori Nishioka, Nobuhiro Kurita, Takashi Iwata, Shinya Morimoto, Tomohiko Miyatani, Masato Komatsu, Hideya Kashihara, Chie Mikami

Published in: Surgery Today | Issue 7/2012

Abstract

Purposes

The inflammatory response after surgery is associated with various postoperative complications. The aim of the present prospective study was to evaluate the effects of Daikenchuto (DKT) (a Japanese herbal medicine) on the inflammatory response in patients following laparoscopic colorectal resection.

Methods

Thirty patients who underwent laparoscopic colectomy for colorectal carcinoma were divided into two groups: a DKT intake group (D group, n = 15) and a control group (C group, n = 15). The D group took 7.5 g/day of DKT from the day after surgery until the 7th postoperative day. The body temperature, heart rate, WBC count, lymphocyte count, C-reactive protein (CRP) level, β-d-glucan level and Candida index were compared between the two groups.

Results

The patients’ mean age in the D group was significantly younger than that in the C group. D3 lymph node dissection was performed more often in the D group. The time until first flatus was significantly shorter in the D group (1.8 ± 0.5 days) than in the C group (2.7 ± 0.5 days). The CRP level was significantly lower in the D group (4.6 ± 0.6 mg/dl) than in the C group (8.3 ± 1.1 mg/dl) on the 3rd postoperative day.

Conclusions

Postoperative DKT administration significantly suppressed the CRP level and shortened the time until first flatus. DKT administration also significantly suppressed postoperative inflammation following surgery for colorectal cancer.

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Title: The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection
Authors: Kozo Yoshikawa
Mitsuo Shimada
Masanori Nishioka
Nobuhiro Kurita
Takashi Iwata
Shinya Morimoto
Tomohiko Miyatani
Masato Komatsu
Hideya Kashihara
Chie Mikami
Publication date: 01-07-2012
Publisher: Springer Japan
Published in: Surgery Today / Issue 7/2012
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-011-0094-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection

Abstract

Purposes

Methods

Results

Conclusions

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Springer Medicine

Abstract

Purposes

Methods

Results

Conclusions

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