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01-03-2015 | Original Article

Effects of Daikenchuto, a Japanese Herb, on Intestinal Motility After Total Gastrectomy: a Prospective Randomized Trial

Authors: Yusuke Akamaru, Tsuyoshi Takahashi, Toshirou Nishida, Takeshi Omori, Kazuhiro Nishikawa, Shoki Mikata, Noriyuki Yamamura, Satoru Miyazaki, Hiroshi Noro, Shuji Takiguchi, Masaki Mori, Yuichiro Doki

Published in: Journal of Gastrointestinal Surgery | Issue 3/2015

Abstract

Purpose

This study aimed to assess the efficacy of daikenchuto (DKT), a commonly prescribed, traditional Japanese herbal medicine, on postoperative intestinal dysfunction after gastric cancer surgery.

Methods

Patients with gastric cancer scheduled for a total gastrectomy were randomly assigned before surgery to receive either no treatment (n = 40; control group) or DKT (7.5 g/day, t.i.d.) for 3 months (n = 41) postoperatively. We examined gastrointestinal motility, stool attributes, the quantity of bowel gas, the quality of life, and the incidence of postoperative ileus.

Results

During the hospital stay, significant differences were observed between the DKT group and controls in the number of stools per day (1.1 ± 0.6 vs 0.8 ± 0.4, respectively; P = 0.037) and stool consistencies (Bristol scale ratings were 3.7 ± 0.8 vs 3.1 ± 0.8, respectively; P = 0.041). The DKT group showed significant reductions in gas volume scores, calculated from abdominal radiographs, at 7 days, 1 month, and 3 months after surgery. The groups did not show significant differences in quality of life scores (based on the Gastrointestinal Symptom Rating Scale) or in the incidence of postoperative ileus.

Conclusion

DKT improved bowel movements, stool properties, and bowel gas. These results suggested that DKT promoted early postoperative bowel functions after total gastrectomy.

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Title: Effects of Daikenchuto, a Japanese Herb, on Intestinal Motility After Total Gastrectomy: a Prospective Randomized Trial
Authors: Yusuke Akamaru
Tsuyoshi Takahashi
Toshirou Nishida
Takeshi Omori
Kazuhiro Nishikawa
Shoki Mikata
Noriyuki Yamamura
Satoru Miyazaki
Hiroshi Noro
Shuji Takiguchi
Masaki Mori
Yuichiro Doki
Publication date: 01-03-2015
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 3/2015
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-014-2730-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of Daikenchuto, a Japanese Herb, on Intestinal Motility After Total Gastrectomy: a Prospective Randomized Trial

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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