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01-02-2015 | Case Report

Our experience of treating undifferentiated gastric carcinoma: report of four cases

Authors: Shunji Endo, Kazuhiro Nishikawa, Terumasa Yamada, Tomo Nakagawa, Hiroaki Fushimi, Tsuyoshi Chihara, Amane Yamauchi, Junichi Nishijima

Published in: Surgery Today | Issue 2/2015

Abstract

Undifferentiated gastric carcinoma is a rare histopathological type of cancer that does not show any differentiation toward adenocarcinoma or squamous cell carcinoma. It is thought to be highly malignant, and is associated with a poor prognosis. However, its clinical behavior has not yet been fully analyzed because of its rarity. We herein review the clinical characteristics and prognoses of patients with undifferentiated gastric carcinoma treated at our institutions. Among 2,651 gastric cancer patients, four (0.2 %) were histopathologically diagnosed to have undifferentiated carcinoma. These four patients included three males and one female. The median age of the patients was 60-year old (range 47–75). Three cases had distant metastases at diagnosis. One of these three cases was treated with chemotherapy alone, and the other two were treated with palliative gastrectomy and chemotherapy. The patient with no distant metastasis underwent curative gastrectomy and adjuvant chemotherapy. All patients died of cancer at a median of 5.4 (range 3.5–7.1) months after their diagnoses.

Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14:101–12.CrossRef

Lauwers GY, Carneiro F, Graham DY, Curado MP, Franceschi S, Montgomery E, et al. Gastric carcinoma. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system. 4th ed. Lyon: International Agency for Research on Cancer; 2010. p. 48–58.

Terayama H, Masuko Y, Horie T, Koike Y, Ozaki S, Sano S, et al. A case of undifferentiated carcinoma at the stomach with unusual lymphnode metastasis (in Japanese with English abstract). J Sapporo City Gen Hosp. 1990;50:65–8.

Matsuzaka T, Ito K, Makihata T, Matsumoto M, Kubokawa M, Kubo H, et al. A case of gastric undifferentiated carcinoma (in Japanese). Jpn J Clin Exp Med. 2001;78:927–9.

Baba H, Fujiwara N, Nakamura H, Tanaka K, Kuwabara H, Tamai S, et al. Adjuvant Chemotherapy of S-1 and CDDP for undifferentiated adenocarcinoma of the stomach (in Japanese with English abstract). Jpn J Cancer Chemother. 2008;35:2051–3.

Takami K, Miura K, Kobayashi T, Moriya T, Shibata C, Kinouchi M, et al. Undifferentiated gastric cancer confirmed by detailed pathological studies. Report of a case (in Japanese with English abstract). Jpn J Gastroenterol Surg. 2008;41:52–6.CrossRef

Matsuzaki H, Ikeda K, Takaki M, Liu M. A case of undifferentiated gastric cancer (in Japanese with English abstract). J Jpn Surg Assoc. 2008;69:810–4.CrossRef

Takashima T, Tayama Y, Inoue K, Hirata K. A case of undifferentiated gastric cancer (in Japanese). Surgery. 2010;72:884–6.

Ueda K, Yamazoe S, Kawazoe Y, Iwasaki Y, Naka T, Yamaue H, et al. Perforated undifferentiated gastric cancer with metastatic small intestinal tumors: a case report (in Japanese with English abstract). J Abdom Emerg Med. 2010;30:937–40.

10.

Yamamoto M, Kobayashi Y, Ochiai M, Terasawa H, Mizumoto Y, Tsubota Y. A rapidly progressed case of undifferentiated gastric cancer (in Japanese with English abstract). J Jpn Surg Assoc. 2012;73:2847–51.CrossRef

11.

Endo S, Miyazaki S, Dousei T, Yamada T, Okuyama M, Fukuchi N, et al. A case of gastric carcinoma that metastasized to the skin and inguinal lymph nodes 7 and 13 many years after gastrectomy (in Japanese with English abstract). Jpn J Gastroenterol Surg. 2013;46:159–66.CrossRef

12.

Tanaka S, Hirata M, Suzuki T, Tsuda T, Inoue K, Teshima H, et al. A case of scirrhous type gastric cancer with skin metastasis which preceded origin cancer diagnosis (in Japanese). J Hiroshima Med Assoc. 1990;43:1884–9.

13.

Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer. 2011;14:113–23.CrossRef

Title: Our experience of treating undifferentiated gastric carcinoma: report of four cases
Authors: Shunji Endo
Kazuhiro Nishikawa
Terumasa Yamada
Tomo Nakagawa
Hiroaki Fushimi
Tsuyoshi Chihara
Amane Yamauchi
Junichi Nishijima
Publication date: 01-02-2015
Publisher: Springer Japan
Published in: Surgery Today / Issue 2/2015
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0793-0

At a glance: The STEP trials

Springer Medicine

Our experience of treating undifferentiated gastric carcinoma: report of four cases

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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