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Acta Diabetologica
Published in: Acta Diabetologica 4/2019

01-04-2019 | Obesity | Original Article

Impact of maternal BMI and gestational diabetes mellitus on maternal and cord blood metabolome: results from the PREOBE cohort study

Authors: Engy Shokry, Linda Marchioro, Olaf Uhl, Mercedes G. Bermúdez, Jose Antonio García-Santos, Mª Teresa Segura, Cristina Campoy, Berthold Koletzko

Published in: Acta Diabetologica | Issue 4/2019

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Abstract

Aims

Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of maternal prepregnancy BMI (pBMI) and GDM on both maternal and cord blood metabolic profiles.

Methods

We used LC–MS/MS to measure 201 metabolites comprising phospholipids (PL), amino acids, non-esterified fatty acids (NEFA), organic acids, acyl carnitines (AC), and Krebs cycle metabolites in maternal plasma at delivery and cord plasma obtained from 325 PREOBE study participants.

Results

Several metabolites were associated with pBMI/GDM in both maternal and cord blood (p < 0.05), while others were specific to either blood sources. BMI was positively associated with leucine, isoleucine, and inflammation markers in both mother and offspring, while β-hydroxybutyric acid was positively associated only in cord blood. GDM showed elevated levels of sum of hexoses, a characteristic finding in both maternal and cord blood. Uniquely in cord blood of offspring born to GDM mothers, free carnitine was significantly lower with the same tendency observed for AC, long-chain NEFA, PL, specific Krebs cycle metabolites, and β-oxidation markers.

Conclusions

Maternal BMI and GDM are associated with maternal and cord blood metabolites supporting the hypothesis of transgenerational cycle of obesity and diabetes.
Appendix
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Metadata
Title
Impact of maternal BMI and gestational diabetes mellitus on maternal and cord blood metabolome: results from the PREOBE cohort study
Authors
Engy Shokry
Linda Marchioro
Olaf Uhl
Mercedes G. Bermúdez
Jose Antonio García-Santos
Mª Teresa Segura
Cristina Campoy
Berthold Koletzko
Publication date
01-04-2019
Publisher
Springer Milan
Published in
Acta Diabetologica / Issue 4/2019
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-019-01291-z

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