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Acta Diabetologica
Published in: Acta Diabetologica 1/2010

01-03-2010 | Short Communication

Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)

Authors: Barbara Szepietowska, Dariusz Moczulski, Natalia Wawrusiewicz-Kurylonek, Wladyslaw Grzeszczak, Maria Gorska, Malgorzata Szelachowska

Published in: Acta Diabetologica | Issue 1/2010

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Abstract

Common polymorphisms in the transcription factor 7-like 2 gene (TCF7L2) have been associated with type 2 diabetes in different populations and recently with LADA, but not with type 1 diabetes. The aim of our study was to investigate association between the rs7903146 polymorphism in the TCF7L2 gene and LADA in Polish patients. Link between the “high risk for type 2 diabetes genotype” with clinical features was analyzed. 68 newly diagnosed patients with LADA and 195 healthy controls were genotyped for the rs7903146 polymorphism in the TCF7L2 gene using the PCR-based RFLP method. Fasting C peptide level was measured by ELISA. We observed increased frequencies of the TT genotype of the rs7903146 polymorphism in the TCF7L2 gene in LADA patients compared to controls (15 vs. 6%, P = 0.03). Fasting C peptide serum concentration was significantly lower in group of patients with LADA carrying the TT genotype (P < 0.01). In conclusion, the data from this study confirmed previous results showing genetic similarities between patients with LADA and type 2 diabetes. Non-autoimmune mechanism may be related to beta cell dysfunction in patients with LADA.
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Metadata
Title
Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)
Authors
Barbara Szepietowska
Dariusz Moczulski
Natalia Wawrusiewicz-Kurylonek
Wladyslaw Grzeszczak
Maria Gorska
Malgorzata Szelachowska
Publication date
01-03-2010
Publisher
Springer Milan
Published in
Acta Diabetologica / Issue 1/2010
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-009-0133-4

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