Skip to main content
Top
Published in: European Journal of Orthopaedic Surgery & Traumatology 7/2019

01-10-2019 | Magnetic Resonance Imaging | General Review • TUMORS - METASTASES

What’s new in management of bone metastases?

Authors: Costantino Errani, Alberto Bazzocchi, Paolo Spinnato, Giancarlo Facchini, Laura Campanacci, Giuseppe Rossi, Andreas F. Mavrogenis

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 7/2019

Login to get access

Abstract

Metastases are the most common malignancy in bone. In patients with bone metastases, especially if a limited expected survival, the indications for surgical treatment are limited, immediate pain relief and improvement in the functional status are important, and complications of treatments are unwanted. Novel medical treatments can offer an effective palliative option in these patients. Advances in interventional radiology and surgery have led to the development of less invasive techniques with the aim to achieve the same clinical results with less surgical morbidity. These include embolization, electrochemotherapy, magnetic resonance imaging-guided high-intensity focused ultrasound, and thermal ablation. Less invasive techniques combine the advantages of less invasive procedures including decreased blood loss, earlier functional recovery and initiation of adjuvant medical therapies and seem to be both effective in pain relief and local tumor control.
Literature
6.
go back to reference Ratasvuori M, Wedin R, Hansen BH et al (2014) Prognostic role of en-bloc resection and late onset of bone metastasis in patients with bone-seeking carcinomas of the kidney, breast, lung, and prostate: SSG study on 672 operated skeletal metastases. J Surg Oncol 110:360–365. https://doi.org/10.1002/jso.23654 CrossRefPubMed Ratasvuori M, Wedin R, Hansen BH et al (2014) Prognostic role of en-bloc resection and late onset of bone metastasis in patients with bone-seeking carcinomas of the kidney, breast, lung, and prostate: SSG study on 672 operated skeletal metastases. J Surg Oncol 110:360–365. https://​doi.​org/​10.​1002/​jso.​23654 CrossRefPubMed
21.
go back to reference Cazzato RL, Arrigoni F, Boatta E et al (2018) Percutaneous management of bone metastases: state of the art, interventional strategies and joint position statement of the Italian College of MSK Radiology (ICoMSKR) and the Italian College of Interventional Radiology (ICIR). Radiol Med Torino 124:34–49. https://doi.org/10.1007/s11547-018-0938-8 CrossRefPubMed Cazzato RL, Arrigoni F, Boatta E et al (2018) Percutaneous management of bone metastases: state of the art, interventional strategies and joint position statement of the Italian College of MSK Radiology (ICoMSKR) and the Italian College of Interventional Radiology (ICIR). Radiol Med Torino 124:34–49. https://​doi.​org/​10.​1007/​s11547-018-0938-8 CrossRefPubMed
44.
go back to reference Mir LM, Belehradek M, Domenge C et al (1991) Electrochemotherapy, a new antitumor treatment: first clinical trial. C R Acad Sci III 313:613–618PubMed Mir LM, Belehradek M, Domenge C et al (1991) Electrochemotherapy, a new antitumor treatment: first clinical trial. C R Acad Sci III 313:613–618PubMed
45.
go back to reference Belehradek M, Domenge C, Luboinski B et al (1993) Electrochemotherapy, a new antitumor treatment. First clinical phase I–II trial. Cancer 72:3694–3700CrossRef Belehradek M, Domenge C, Luboinski B et al (1993) Electrochemotherapy, a new antitumor treatment. First clinical phase I–II trial. Cancer 72:3694–3700CrossRef
46.
go back to reference Colombo GL, Matteo SD, Mir LM (2008) Cost-effectiveness analysis of electrochemotherapy with the Cliniporatortrade mark vs other methods for the control and treatment of cutaneous and subcutaneous tumors. Ther Clin Risk Manag 4:541–548CrossRef Colombo GL, Matteo SD, Mir LM (2008) Cost-effectiveness analysis of electrochemotherapy with the Cliniporatortrade mark vs other methods for the control and treatment of cutaneous and subcutaneous tumors. Ther Clin Risk Manag 4:541–548CrossRef
51.
go back to reference Horiuchi A, Nikaido T, Mitsushita J et al (2000) Enhancement of antitumor effect of bleomycin by low-voltage in vivo electroporation: a study of human uterine leiomyosarcomas in nude mice. Int J Cancer 88:640–644CrossRef Horiuchi A, Nikaido T, Mitsushita J et al (2000) Enhancement of antitumor effect of bleomycin by low-voltage in vivo electroporation: a study of human uterine leiomyosarcomas in nude mice. Int J Cancer 88:640–644CrossRef
Metadata
Title
What’s new in management of bone metastases?
Authors
Costantino Errani
Alberto Bazzocchi
Paolo Spinnato
Giancarlo Facchini
Laura Campanacci
Giuseppe Rossi
Andreas F. Mavrogenis
Publication date
01-10-2019

Other articles of this Issue 7/2019

European Journal of Orthopaedic Surgery & Traumatology 7/2019 Go to the issue