Top

Published in:

01-01-2006 | Review Article

Image-guided ablation of painful metastatic bone tumors: a new and effective approach to a difficult problem

Authors: Matthew R. Callstrom, J. William Charboneau, Matthew P. Goetz, Joseph Rubin, Thomas D. Atwell, Michael A. Farrell, Timothy J. Welch, Timothy P. Maus

Published in: Skeletal Radiology | Issue 1/2006

Abstract

Painful skeletal metastases are a common problem in cancer patients. Although external beam radiation therapy is the current standard of care for cancer patients who present with localized bone pain, 20–30% of patients treated with this modality do not experience pain relief, and few further options exist for these patients. For many patients with painful metastatic skeletal disease, analgesics remain the only alternative treatment option. Recently, image-guided percutaneous methods of tumor destruction have proven effective for treatment of this difficult problem. This review describes the application, limitations, and effectiveness of percutaneous ablative methods including ethanol, methyl methacrylate, laser-induced interstitial thermotherapy (LITT), cryoablation, and percutaneous radiofrequency ablation (RFA) for palliation of painful skeletal metastases.

Rosenthal DI, Alexander A, Rosenberg AE, Springfield D. Ablation of osteoid osteomas with a percutaneously placed electrode: a new procedure. Radiology 1992;183:29–33PubMed

Rosenthal DI, Springfield DS, Gebhardt MC, Rosenberg AE, Mankin HJ. Osteoid osteoma: percutaneous radio-frequency ablation. Radiology 1995;197:451–454PubMed

Rosenthal DI, Hornicek FJ, Wolfe MW, Jennings LC, Gebhardt MC, Mankin HJ. Percutaneous radiofrequency coagulation of osteoid osteoma compared with operative treatment. J Bone Joint Surg Am 1998;80:815–821PubMed

Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology 2003;229:171–175PubMedCrossRef

Nielsen OS, Munro AJ, Tannock IF. Bone metastases: pathophysiology and management policy. J Clin Oncol 1991;9:509–524PubMed

Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain 1997. p. 1–18

Mantyh PW, Clohisy DR, Koltzenburg M, Hunt SP. Molecular mechanisms ofcancer pain. Nat Rev Cancer 2002;2:201–209CrossRefPubMed

Mannion RJ, Woolf CJ. Pain mechanisms and management: a centralperspective. Clin J Pain 2000;16:S144–S156CrossRefPubMed

Watkins LR, Goehler LE, Relton J, Brewer MT, Maier SF. Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia. Brain Res 1995;692:244–250CrossRefPubMed

10.

Sorkin LS, Xiao WH, Wagner R, Myers RR. Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neuroscience 1997;81:255–262CrossRefPubMed

11.

Woolf CJ, Allchorne A, Safieh-Garabedian B, Poole S. Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha. Br J Pharmacol 1997;121:417–424PubMedCrossRef

12.

Opree A, Kress M. Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin. J Neurosci 2000;20:6289–6293PubMed

13.

Davar G, Hans G, Fareed MU, Sinnott C, Strichartz G. Behavioral signs of acute pain produced by application of endothelin-1 to rat sciatic nerve. Neuroreport 1998;9:2279–2283PubMedCrossRef

14.

Gokin AP, Fareed MU, Pan HL, Hans G, Strichartz GR, Davar G. Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats. J Neurosci 2001;21:5358–5366PubMed

15.

Zhou Z, Davar G, Strichartz G. Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1. J Neurosci 2002;22:6325–6330PubMed

16.

Massie MJ, Holland JC. The cancer patient with pain: psychiatric complications and their management. J Pain Symptom Manage 1992;7:99–109CrossRefPubMed

17.

Spiegel D, Sands S, Koopman C. Pain and depression in patients with cancer. Cancer 1994;74:2570–2578PubMedCrossRef

18.

Jeremic B, Shibamoto Y, Acimovic L, et al. A randomized trial of three single-dose radiation therapy regimens in the treatment of metastatic bone pain. Int J Radiat Oncol Biol Phys 1998;42:161–167CrossRefPubMed

19.

Price P, Hoskin PJ, Easton D, Austin D, Palmer SG, Yarnold JR. Prospective randomised trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases. Radiother Oncol 1986;6:247–255PubMedCrossRef

20.

Cole DJ. A randomized trial of a single treatment versus conventional fractionation in the palliative radiotherapy of painful bone metastases. Clin Oncol (R Coll Radiol) 1989;1:59–62

21.

Gaze MN, Kelly CG, Kerr GR, et al. Pain relief and quality of life following radiotherapy for bone metastases: a randomised trial of two fractionation schedules. Radiother Oncol 1997;45:109–116CrossRefPubMed

22.

Barton PP, Waneck RE, Karnel FJ, Ritschl P, Kramer J, Lechner GL. Embolization of bone metastases. J Vasc Interv Radiol 1996;7:81–88PubMedCrossRef

23.

Cloft HJ, Dion JE. Preoperative and palliative embolization of vertebral tumors. Neuroimaging Clin N Am 2000;10:569–578PubMed

24.

Uemura A, Fujimoto H, Yasuda S, et al. Transcatheter arterial embolization for bone metastases from hepatocellular carcinoma. Eur Radiol 2001;11:1457–1462CrossRefPubMed

25.

Chiras J, Adem C, Vallee JN, Spelle L, Cormier E, Rose M. Selective intra-arterial chemoembolization of pelvic and spine bone metastases. Eur Radiol 2004;14:1774–1780CrossRefPubMed

26.

Gangi A, Kastler B, Klinkert A, Dietemann JL. Injection of alcohol into bone metastases under CT guidance. J Comput Assist Tomogr 1994;18:932–935PubMedCrossRef

27.

Weill A, Chiras J, Simon JM, Rose M, Sola-Martinez T, Enkaoua E. Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement. Radiology 1996;199:241–247PubMed

28.

Weill A, Kobaiter H, Chiras J. Acetabulum malignancies: technique and impact on pain of percutaneous injection of acrylic surgical cement. Eur Radiol 1998;8:123–129CrossRefPubMed

29.

Gangi A, Dietemann JL, Schultz A, Mortazavi R, Jeung MY, Roy C. Interventional radiologic procedures with CT guidance in cancer pain management. Radiographics 1996;16:1289–1304, discussion 1304–1306PubMed

30.

Gangi A, Guth S, Imbert JP, Marin H, Dietemann J-L. Percutaneous vertebroplasty: indications, technique, and results. Radiographics 2003;23:10eCrossRef

31.

Deramond H, Depriester C, Galibert P, Le Gars D. Percutaneous vertebroplasty with polymethylmethacrylate. Technique, indications, and results. Radiol Clin North Am 1998;36:533–546CrossRefPubMed

32.

Peh WC, Gilula LA. Percutaneous vertebroplasty: indications, contraindications, and technique. Br J Radiol 2003;76:69–75CrossRefPubMed

33.

Mathis JM, Barr JD, Belkoff SM, Barr MS, Jensen ME, Deramond H. Percutaneous vertebroplasty: a developing standard of care for vertebral compression fractures. Am J Neuroradiol 2001;22:373–381PubMed

34.

Peh WC, Gilula LA. Additional value of a modified method of intraosseous venography during percutaneous vertebroplasty. Am J Roentgenol 2003;180:87–91

35.

Kallmes DF, Jensen ME. Percutaneous vertebroplasty. Radiology 2003;229:27–36PubMedCrossRef

36.

Wong W, Mathis J. Is intraosseous venography a significant safety measure in performance of vertebroplasty? J Vasc Interv Radiol 2002;13:137–138PubMedCrossRef

37.

Cyteval C, Sarrabere MP, Roux JO, et al. Acute osteoporotic vertebral collapse: open study on percutaneous injection of acrylic surgical cement in 20 patients. Am J Roentgenol 1999;173:1685–1690

38.

Cotten A, Boutry N, Cortet B, et al. Percutaneous vertebroplasty: state of the art. Radiographics 1998;18:311–320, discussion 320–323PubMed

39.

Cotten A, Deprez X, Migaud H, Chabanne B, Duquesnoy B, Chastanet P. Malignant acetabular osteolyses: percutaneous injection of acrylic bone cement. Radiology 1995;197:307–310PubMed

40.

Cotten A, Demondion X, Boutry N, et al. Therapeutic percutaneous injections in the treatment of malignant acetabular osteolyses. Radiographics 1999;19:647–653PubMed

41.

Hokotate H, Baba Y, Churei H, Nakajo M, Ohkubo K, Hamada K. Pain palliation by percutaneous acetabular osteoplasty for metastatic hepatocellular carcinoma. Cardiovasc Intervent Radiol 2001;24:346–348CrossRefPubMed

42.

Marcy PY, Palussiere J, Descamps B, et al. Percutaneous cementoplasty for pelvic bone metastasis. Support Care Cancer 2000;8:500–503CrossRefPubMed

43.

Hierholzer J, Anselmetti G, Fuchs H, Depriester C, Koch K, Pappert D. Percutaneous osteoplasty as a treatment for painful malignant bone lesions of the pelvis and femur. J Vasc Interv Radiol 2003;14:773–777PubMed

44.

Gröenemeyer DH, Schirp S, Gevargez A. Image-guided percutaneous thermal ablation of bone tumors. Acad Radiol 2002;9:467–477CrossRefPubMed

45.

Dodd GD III, Frank MS, Aribandi M, Chopra S, Chintapalli KN. Radiofrequency thermal ablation: computer analysis of the size of the thermal injury created by overlapping ablations. Am J Roentgenol 2001;177:777–782

46.

Chosy SG, Nakada SY, Lee FT Jr, Warner TF. Monitoring renal cryosurgery: predictors of tissue necrosis in swine. J Urol 1998;159:1370–1374CrossRefPubMed

47.

Campbell SC, Krishnamurthi V, Chow G, Hale J, Myles J, Novick AC. Renal cryosurgery: experimental evaluation of treatment parameters. Urology 1998;52:29–33, discussion 33–34CrossRefPubMed

48.

Sewell P, Jackson M, Dhillon G. Percutaneous MRI guided cryosurgery of bone tumors. Radiology 2002;225(P):514

49.

Daut RL, Cleeland CS, Flanery RC. Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases. Pain 1983;17:197–210CrossRefPubMed

50.

Cleeland CS, Gonin R, Hatfield AK, et al. Pain and its treatment in outpatients with metastatic cancer. N Engl J Med 1994;330:592–596CrossRefPubMed

51.

Dupuy DE, Hong R, Oliver B, Goldberg SN. Radiofrequency ablation of spinal tumors: temperature distribution in the spinal canal. Am J Roentgenol 2000;175:1263–1266

52.

Gröenemeyer DHW, Schirp S, Gevargez A. Image-guided radiofrequency ablation of spinal tumors: preliminary experience with an expandable array electrode. Cancer J 2002;8:33–39PubMed

53.

Patti JW, Neeman Z, Wood BJ. Radiofrequency ablation for cancer-associated pain. J Pain 2002 ;3:471–473CrossRefPubMed

54.

Ohhigashi S, Nishio T, Watanabe F, Matsusako M. Experience with radiofrequency ablation in the treatment of pelvic recurrence in rectal cancer: report of two cases. Dis Colon Rectum 2001;44:741–745CrossRefPubMed

55.

Ogunbiyi OA, McKenna K, Birnbaum EH, Fleshman JW, Kodner IJ. Aggressive surgical management of recurrent rectal cancer—is it worthwhile? Dis Colon Rectum 1997;40:150–155CrossRefPubMed

56.

Wong CS, Cummings BJ, Brierley JD, et al. Treatment of locally recurrent rectal carcinoma—results and prognostic factors. Int J Radiat Oncol Biol Phys 1998;40:427–435CrossRefPubMed

57.

Schaefer O, Lohrmann C, Herling M, Uhrmeister P, Langer M. Combined radiofrequency thermal ablation and percutaneous cementoplasty treatment of a pathologic fracture. J Vasc Interv Radiol 2002;13:1047–1050PubMedCrossRef

58.

Callstrom MR, Charboneau JW, Goetz MP, et al. Painful metastases involving bone: feasibility of percutaneous CT- and US-guided radio-frequency ablation. Radiology 2002;224:87–97PubMedCrossRef

59.

Goetz M, Rubin J, Callstrom M, et al. Percutaneous US and CT-guided radiofrequency ablation of painful metastases involving bone. ASCO 2002, May 24–30, p 1544

60.

Goetz MP, Callstrom MR, Charboneau JW, et al. Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol 2004;22:300–306CrossRefPubMed

61.

Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole RM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 2001;94:149–158CrossRefPubMed

Title: Image-guided ablation of painful metastatic bone tumors: a new and effective approach to a difficult problem
Authors: Matthew R. Callstrom
J. William Charboneau
Matthew P. Goetz
Joseph Rubin
Thomas D. Atwell
Michael A. Farrell
Timothy J. Welch
Timothy P. Maus
Publication date: 01-01-2006
Publisher: Springer-Verlag
Published in: Skeletal Radiology / Issue 1/2006
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-005-0003-2

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Image-guided ablation of painful metastatic bone tumors: a new and effective approach to a difficult problem

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2006

MRI features of extraskeletal myxoid chondrosarcoma

Diaphyseal chondroblastoma in a long bone: first report

MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome

December 2005

Sarcoidosis presenting as prepatellar bursitis

Periprosthetic soft tissue recurrence of chondroblastoma after attempted en bloc excision from the proximal humerus