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01-12-2011 | Original Article

Vertebral fracture and cause-specific mortality: a prospective population study of 3,210 men and 3,730 women with 30 years of follow-up

Authors: Ville Puisto, Harri Rissanen, Markku Heliövaara, Olli Impivaara, Tuomas Jalanko, Heikki Kröger, Paul Knekt, Arpo Aromaa, Ilkka Helenius

Published in: European Spine Journal | Issue 12/2011

Abstract

Introduction

Vertebral fractures predict mortality, but little is known about their associations with the causes of death. We studied vertebral fractures for prediction of cause-specific mortality.

Material and methods

A nationally representative sample of 3,210 men and 3,730 women participated Mini-Finland health survey in 1978–1980. Vertebral fractures at the Th1–Th12 levels were identified from chest radiographs at baseline. Cox’s proportional hazard model was used to estimate the strength of association between vertebral fracture and mortality.

Results

The relative risk (95% confidence interval) of death from natural causes was 1.49 (0.89–2.48) in men and 0.89 (0.60–1.31) in women with vertebral fractures (adjusted for age, body mass index, serum 25-hydroxyvitamin D, educational level, smoking, alcohol intake, physical activity and self-rated general health). Among women the adjusted relative risk of an injury death was 8.51 (3.48–20.77), whereas none of the men with vertebral fracture died due to an injury.

Conclusion

The patterns of mortality predicted by fracture in the thoracic spine differ between men and women.

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Title: Vertebral fracture and cause-specific mortality: a prospective population study of 3,210 men and 3,730 women with 30 years of follow-up
Authors: Ville Puisto
Harri Rissanen
Markku Heliövaara
Olli Impivaara
Tuomas Jalanko
Heikki Kröger
Paul Knekt
Arpo Aromaa
Ilkka Helenius
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue 12/2011
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-011-1852-0

At a glance: The STEP trials

Springer Medicine

Vertebral fracture and cause-specific mortality: a prospective population study of 3,210 men and 3,730 women with 30 years of follow-up

Abstract

Introduction

Material and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Material and methods

Results

Conclusion

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