Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Osteoporosis International
Published in: Osteoporosis International 1/2004

01-01-2004 | Original Article

Mortality after osteoporotic fractures

Authors: O. Johnell, J. A. Kanis, A. Odén, I. Sernbo, I. Redlund-Johnell, C. Petterson, C. De Laet, B. Jönsson

Published in: Osteoporosis International | Issue 1/2004

Login to get access

Abstract

The aim of this study was to examine the pattern of mortality following osteoporotic fractures at the spine, shoulder, hip, and forearm. We studied 2,847 patients with fractures at these sites identified from the radiology department in Malmö, Sweden. Poisson regression was used to compute mortality immediately after the fracture and with time. Mortality immediately after fracture was significantly higher in fracture cases than in the general population except for forearm fractures in both men and women. Mortality was higher in men than in women, but not different when adjusted for sex-specific population risks. For spine, shoulder, and hip fracture, mortality fell after the 1st year, an effect that was most marked for patients with spine fractures. The decrease in mortality risk with time was significant for hip, vertebral, and shoulder fracture. We conclude that the risk of death is increased in patients with osteoporotic fractures and that the highest risk is found immediately after the fracture event. The decreasing mortality with time after fracture may be due in part to a decrease in deaths causally related to the fracture. The extent to which early intervention for osteoporosis might avoid some of these deaths is unknown.
Literature
1.
Cooper C, Atkinson EJ, Jacobsen SJ, O’Fallon WM, Melton LJ III (1993) Population-based study of survival after osteoporotic fractures. AM J Epidemiol 137:1001–1005PubMed
2.
Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882PubMed
3.
Johnell O, Haglund B (1999) Co-morbidity and mortality in hip fracture patients: a population-based study. J Bone Miner Res 14[Suppl 1]:S160
4.
Cauley JA, Thompson DE, Ensrud KC, Scott JC, Black D (2000) Risk of mortality following clinical fractures. Osteoporos Int 11:556–561CrossRefPubMed
5.
Ismail AA, O’Neill TW, Cooper C et al on behalf of the EPOS Study Group (1998) Mortality associated with vertebral deformity in men and women: results from the European Prospective Osteoporosis Study (EPOS). Osteoporos Int 8:291–297CrossRefPubMed
6.
Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA (1992) Race and sex differences in mortality following fracture in hip. Am J Public Health 82:1147–1150PubMed
7.
Magaziner J, Simonsick EM, Kashner M, Hebel JR, Kenzora JE (1989) Survival experience of aged hip fracture patients. Am J Public Health 73:274–278
8.
Todd C, Freeman C, Camilleri-Ferrante C, Palmer CR, Hyder A, Laxton CE, Parker M, Payne BV, Rushton N (1995) Differences in mortality after fracture of the hip. BMJ 310:904–908PubMed
9.
Todd C, Freeman C, Camilleri-Ferrant C, Laxton C, Murrel P, Palmer C, Parker M, Payne B, Rushton N (1999) Anglian audit of hip fracture II. Institute of Public Health, University of Cambridge, Cambridge
10.
Weiss NS, Liff JM, Ure CL, Ballard JH, Abbott GH, Daling JR (1983) Mortality in women following hip fracture. J Chron Dis 12:879–882
11.
Sernbo I, Johnell O (1993) Consequences of a hip fracture: a prospective study over 1 year. Osteoporos Int 3:148–153
12.
Melton LJ III, Therneau TM, Larson DR (1998) Long-term trends in hip fracture prevalence: the influence of hip fracture incidence and survival. Osteoporos Int 8:68–74CrossRefPubMed
13.
Forsén L, Søgaard AJ, Meyer HE, Edna T-H, Kopjar B (1999) Survival after hip fracture: short- and long-term excess mortality according to age and gender. Osteoporos Int 10:73–78CrossRefPubMed
14.
Browner WS, Pressman AR, Nevitt MC, Cummings SR, for the Study of Osteoporotic Fractures Research Group (1996) Mortality following fractures in older women. Arch Intern Med 156:1521–1525PubMed
15.
Browner WS, Seeley DG, Vogt TM, Cummings SR (1991) Non-traumatic mortality in elderly women with low bone mineral density. Lancet 338:355–358PubMed
16.
Johansson C, Black D, Johnell O, Odén A, Mellström D (1998) Bone mineral density is a predictor of survival. Calcif Tissue Int 63:190–196CrossRefPubMed
17.
Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby A (2003) The components of excess mortality after hip fracture. Bone 32:468–473CrossRefPubMed
18.
Kanis JA, Johnell O, Odén A, Sernbo I, Redlund-Johnell I, Dawson A, De Laet C, Jönsson B (2000) Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int 11:669–674CrossRefPubMed
19.
Jonsson B, Gardsell P, Johnell O, Redlund-Johnell I, Sernbo I (1994) Remembering fractures: fracture registration and proband recall in Southern Sweden. J Epidemiol Comm Health 48:489–490
20.
Hasserius R, Karlsson MK, Nilsson BE, Redlund-Johnell I, Johnell O (2003) Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: a 10 year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study. Osteoporos Int 14:61–68PubMed
21.
Ensrud KE, Thompson DE, Cauley JE et al (2000) Prevalent vertebral deformities predict mortality and hospitalisation in older women with low bone mass. J Amer Geriatr Soc 48:241–249
22.
Ismail AA, O’Neill TW, Cooper C et al (1998) Mortality associated with vertebral deformity in men and women: results from the European Prospective Osteoporosis Study (EPOS). Osteoporos Int 8:821–827CrossRef
23.
Kado DM, Browner WS, Palermo L, Nevitt MC, Genant HK, Cummings SR (1999) Vertebral fractures and mortality in older women. The study of osteoporotic fractures. Arch Intern Med 159:1215–1220PubMed
Metadata
Title
Mortality after osteoporotic fractures
Authors
O. Johnell
J. A. Kanis
A. Odén
I. Sernbo
I. Redlund-Johnell
C. Petterson
C. De Laet
B. Jönsson
Publication date
01-01-2004
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 1/2004
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1490-4

Other articles of this Issue 1/2004

Osteoporosis International 1/2004 Go to the issue

Original Article

Bone mineral density and prevalent vertebral fractures in men and women

Original Article

Establishment of BMD reference plots and determination of peak BMD at multiple skeletal regions in mainland Chinese women and the diagnosis of osteoporosis

Original Article

Radiocalcium absorption is reduced in postmenopausal women with vertebral and most types of peripheral fractures

Opinion

Adherence with hip protectors: a proposal for standardised definitions

Original Article

The risk and burden of vertebral fractures in Sweden

Original Article

A method for assessment of the shape of the proximal femur and its relationship to osteoporotic hip fracture