Top

Published in:

01-01-2017 | Original Article

Evaluation of the healing effect of honey and colostrum in treatment of cutaneous wound in rat

Authors: Nader Tanideh, Ehsan Abdordideh, Seyedeh Leili Asadi Yousefabad, Sajad Daneshi, Omid Koohi Hosseinabadi, Soleiman Mohammadi Samani, Amin Derakhshan far

Published in: Comparative Clinical Pathology | Issue 1/2017

Abstract

Wound healing is a dynamic and complex process of replacing devitalized and missing cellular structures and tissue layers. Due to the importance of wound healing, this investigation was designed to compare the effect of treatment using honey and colostrum on wound-healing process in rats. In this study, 80 adult female Sprague Dawley rats were randomly divided into four groups as negative control group, groups II, III, and IV were treated by honey, bovine colostrum, and honey + colostrum, respectively. Rats were anesthetized, hair was removed from the back, and then a wound was made on the back. Visual observation, histopathological examination, and biomechanical study were performed on days 3, 7, 14, and 21 after operation. Wound area in rats which taken colostrum and honey was lower than other groups. Promotion of wound contraction and epithelialization in rats that were treated with honey and colostrum was better than the others. Biomechanical parameters in animals were treated by colostrum and honey significantly more than other rats. A combination of honey and colostrum on wounds can enhance healing better than honey and colostrum separately.

Alizadeh AM, Sohanaki H, Khaniki M, Mohaghgheghi MA, Ghmami G, Mosavi M (2011) The effect of Teucrium Polium Hney on the wound healing and tensile strength in rat. Iran J Basic Med 14(6):499

Allen K, Hutchinson G, Molan P (2000) The potential for using honey to treat wounds infected with MRSA and VRE. In: First World Wound Healing Congress, pp 10–13

Anyanechi C, Saheeb B (2015) Honey and wound dehiscence: a study of surgical wounds in the mandibular bed. Niger J Clin Pract 18:251–255CrossRefPubMed

Cheng PG, Phan CW, Sabaratnam V, Abdullah N, Abdulla MA, Kuppusamy UR (2013) Polysaccharides-rich extract of Ganoderma lucidum (MA Curtis: Fr.) P. Karst accelerates wound healing in streptozotocin-induced diabetic rats. Evid Based Complement Alternat Med

Cooke J, Dryden M, Patton T, Brennan J, Barrett J (2015) The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide. BMC res notes 8:20CrossRefPubMedPubMedCentral

Dluya T (2015) Critical review: antioxidant properties and antibiotic mechanism of honey against infectious diseases. Int J Adv Life Sci Technol 2:16–24CrossRef

Esmaeili H, Dehghan M, Rabbani M, Haririan E (2014) Effect of bovine colostrum on open wound healing in Guinea pigs. Razi J Med Sci 21:66–74

Gauthier S, Pouliot Y, Maubois J (2006) Growth factors from bovine milk and colostrum: composition, extraction and biological activities. Lait 86:99–125CrossRef

Ghasemi S, Emami M, Maleki M, Fathi B (2012) Histhopathologic evaluation of curative impact of Aloe vera L. fresh gel on healing of experimental infected full-thickness open wounds induced with Staphylococcus aureus in dogs. Iran J Vet Surg 4:103–114

Ginjala V, Pakkanen R (1998) Determination of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor 1 (IGF-1) in bovine colostrum samples. J Immunoass Immunochem 19:195–207CrossRef

Hampton S, Coulborn A, Tadej M, Bree-Aslan C (2011) Using a superabsorbent dressing and antimicrobial for a venous ulcer. Br J Nurs 20:38–S43CrossRef

Jenkins R, Burton N, Cooper R (2013) Proteomic and genomic analysis of methicillin-resistant Staphylococcus aureus (MRSA) exposed to manuka honey in vitro demonstrated down-regulation of virulence markers. J Antimicrob Chemother:1–13

Jull A, Walker N, Deshpande S (2013) Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2(2)

Kamer E, Unalp HR, Gundogan O, Diniz G, Ortac R, Olukman M, Derici H, Onal M (2010) Effect of ascorbic acid on incisional wound healing in streptozotocin-induced diabetic rats. Wounds 22(2):27–31PubMed

Kshirsagar AY, Vekariya MA, Gupta V, Pednekar AS, Mahna A, Patankar R, Shaikh A, Nagur B (2015) A comparative study of colostrum dressing versus conventional dressing in deep wounds. J Clin Diagn Res 9(4):1

Kwakman P, Zaat S (2012) Antibacterial components of honey. IUBMB life 64:48–55CrossRefPubMed

Mahendran S, Kumarasamy D (2015) Antimicrobial activity of some honey samples against pathogenic bacteria. Int Lett Nat Sci 7:15–20CrossRef

Mohammed H, Salama M, El Lenjawi B, Hassan I (2015) Using honey in post-excision malignant melanoma ulcers. J Lymphoedema 7:41–45

Molan P (2011) The evidence and the rationale for the use of honey as wound dressing. Wound Prac Res 19:204–220

Nisbet HO, Nisbet C, Yarim M, Guler A, Ozak A (2010) Effects of three types of honey on cutaneous wound healing. Wounds Compendium Clin Res Prac 22(11):275–283

Noda K, Umeda M, Ono T (1984) Transforming growth Factors A and B (TGF A & B) in bovine colostrum were involved in normal cellular activities. Gann 75:109–112PubMed

Oryan A, Moshiri A (2011) A long term study on the role of exogenous human recombinant basic fibroblast growth factor on the superficial digital flexor tendon healing in rabbits. J Musculoskelet Neuronal Interact 11:185–195PubMed

Oryan A, Zaker S (1998) Effects of topical application of honey on cutaneous wound healing in rabbits. J Vet Med A 45:181–188CrossRef

Reddy N (2013) Lantana camara Linn. chemical constituents and medicinal properties: a review. Scholars Acad J Pharmacy 2:445–448

Sanjay C, Ritura J (2015) Deep wounds: colostrum dressing versus conventional dressing. Int j interdiscip multidiscip stud 2:24–28

Sazegar G, Attarzadeh Hosseini SR, Behravan E (2011) The effects of supplemental zinc and honey on wound healing in rats. Iran J Basic Med Sci 14:391–398PubMedPubMedCentral

Shin JM, Jeong YJ, Cho HJ, Park KK, Chung IK, Lee IK, Kwak JY, Chang HW, Kim CH, Moon SK, Kim WJ (2013) Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells. PLoS One 8(7):e69380CrossRefPubMedPubMedCentral

Stelwagen K, Carpenter E, Haigh B, Hodgkinson A, Wheeler T (2009) Immune components of bovine colostrum and milk. J Anim Sci 87:3–9CrossRefPubMed

Stout E, McKessor A (2012) Glycerin-based hydrogel for infection control. Adv Wound Care 1:48–51CrossRef

Takayama Y, Kitsunai K, Mizumachi K (2001) Factors in bovine colostrum that enhance the migration of human fibroblasts in type I collagen gels. Biosci Biotechnol Biochem 65(12):2776–2779CrossRefPubMed

Tan HT, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur BS (2009) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey. BMC Complement Altern Med 9(1):34CrossRefPubMedPubMedCentral

Tan M, Hasan Adli D, Tumiran M, Abdulla M, Yusoff K (2012) The efficacy of Gelam honey dressing towards excisional wound healing. Evid Based Complement Alternat Med :1–6

Thapa B (2005) Health factors in colostrum. Indian J Pediatr 72:579–581CrossRefPubMed

Torre C, Jeusette I, Serra M, Brazis P, Puigdemont A (2006) Bovine colostrum increases proliferation of canine skin fibroblasts. J Nutr 136:2058–2060

Vandamme L, Heyneman A, Hoeksema H, Verbelen J, Monstrey S (2013) Honey in modern wound care: a systematic review. Burns 39:1514–1525CrossRefPubMed

Voicu G, Oprea O, Vasile B, Andronescu E (2013) Antibacterial activity of zinc oxide–gentamicin hybrid material. Digest J Nanomater Biostruc 8:1191–1203

Yaghoobi R, Kazerouni A (2013) Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: a review. Jundishapur J Nat Pharm Prod 8:100–104CrossRefPubMedPubMedCentral

Title: Evaluation of the healing effect of honey and colostrum in treatment of cutaneous wound in rat
Authors: Nader Tanideh
Ehsan Abdordideh
Seyedeh Leili Asadi Yousefabad
Sajad Daneshi
Omid Koohi Hosseinabadi
Soleiman Mohammadi Samani
Amin Derakhshan far
Publication date: 01-01-2017
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 1/2017
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-016-2347-5

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Evaluation of the healing effect of honey and colostrum in treatment of cutaneous wound in rat

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2017

High platelet count and high probability of CALR detection in myeloproliferative neoplasms

Butyrylcholinesterase activity in dairy cows naturally infected by Dictyocaulus viviparous and treated with eprinomectin

Retraction note to: Prevalence of the C282Y and H63D mutations of the HFE hemochromatosis gene in Azerian major β-thalassemia and iron overload

Efficacy of ARACNE algorithm for inferring canine B-cell lymphoma gene regulatory network (GRN)

Pathology of muscular steatosis in the bovine species: report of two spontaneously arising cases and comparative overview of the condition

Gastroprotective potential of melatonin versus melatonin loaded niosomes on gastric ulcer healing in rats