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Comparative Clinical Pathology
Published in: Comparative Clinical Pathology 5/2014

01-09-2014 | Original Article

Ultrastructural study on the photoreceptor layer in streptozotocin-induced diabetic rats

Authors: Arash Goodarzi, Arash Esfandiari, Arman Dehghansheibani

Published in: Comparative Clinical Pathology | Issue 5/2014

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Abstract

The aim of this research was to investigate the ultrastructure of the photoreceptor layer of diabetic male Wistar rat retina. Ten apparently healthy Wistar adult rats (aged 75 days) were used and divided into two groups: (1) control group and (2) diabetic group (injected intraperitoneally with streptozotocin 90 mg/kg). Samples were taken as small pieces from the retina near the optic disc and studied using a transmission electron microscope. Results showed that outer segments loss, scattered inner segments, and condense and pyknotic nuclei and karyolysis were obvious in diabetic group. The quantitative evaluations of different layers of photoreceptor cells showed that a significant decrease was observed in outer segments, inner segments, and outer nuclear layers in diabetic group compared with control group. This study concluded that diabetes caused major signs of pathology in the ultrastructure of photoreceptor layer of the rat retina.
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Metadata
Title
Ultrastructural study on the photoreceptor layer in streptozotocin-induced diabetic rats
Authors
Arash Goodarzi
Arash Esfandiari
Arman Dehghansheibani
Publication date
01-09-2014
Publisher
Springer London
Published in
Comparative Clinical Pathology / Issue 5/2014
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-013-1777-6

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