Important role of calcium chloride in preventing carbon monoxide generation during desflurane degradation with alkali hydroxide-free carbon dioxide absorbents

We investigated whether calcium chloride (CaCl₂), a supplementary additive in carbon dioxide (CO₂) absorbents, could affect carbon monoxide (CO) production caused by desflurane degradation, using a Japanese alkali-free CO₂ absorbent Yabashi Lime^®-f (YL-f), its CaCl₂-free and 1% CaCl₂-added derivatives, and other commercially available alkali-free absorbents with or without CaCl₂. The reaction between 1 L of desflurane gas (3–10%) and 20 g of desiccated specimen was performed in an artificial closed-circuit anesthesia system for 3 min at 20 or 40 °C. The CO concentration was measured using a gas chromatograph equipped with a semiconductor sensor detector. The systems were validated by detecting dose-dependent CO production with an alkali hydroxide-containing CO₂ absorbent, Sodasorb^®. Compared with YL-f, the CaCl₂-free derivative caused the production of significantly more CO, while the 1% CaCl₂-added derivative caused the production of a comparable amount of CO. These phenomena were confirmed using commercially available absorbents AMSORB^® PLUS, an alkali-free absorbent with CaCl₂, and LoFloSorb™, an alkali-free absorbent without CaCl₂. These results suggest that CaCl₂ plays an important role in preventing CO generation caused by desflurane degradation with alkali hydroxide-free CO₂ absorbents like YL-f.