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Journal of Anesthesia
Published in: Journal of Anesthesia 6/2017

01-12-2017 | Original Article

Combined intraoperative paracetamol and preoperative dexamethasone reduces postoperative sore throat: a prospective randomized study

Authors: Jiwon Lee, Hee-Pyoung Park, Mu-Hui Jeong, Hyun-Chang Kim

Published in: Journal of Anesthesia | Issue 6/2017

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Abstract

Purpose

Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia.

Methods

A total of 226 patients scheduled for urologic surgery under general anesthesia were randomly assigned to one of two groups. In the DexaPara group (n = 113), dexamethasone (10 mg) and paracetamol (1000 mg) was infused. In the Dexa group (n = 113), dexamethasone (10 mg) alone was given. POST, hoarseness, and dysphagia were monitored. The postoperative wound pain score and perioperative opioid requirements were compared. In addition, complications related to opioids were compared between the groups.

Results

The overall incidence of POST was lower in the DexaPara group than in the Dexa group [42 (37%) vs. 72 (64%), p < 0.001]. The incidence of POST while resting at postoperative 1 and 6 h was lower in the DexaPara group than in the Dexa group (p = 0.008 and p = 0.004, respectively). The incidence of postoperative nausea, vomiting, drowsiness, shivering, and headache was comparable between the groups.

Conclusions

Paracetamol and dexamethasone infusion reduced the incidence of POST without serious complications in patients for urologic surgery under general anesthesia.
Appendix
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Metadata
Title
Combined intraoperative paracetamol and preoperative dexamethasone reduces postoperative sore throat: a prospective randomized study
Authors
Jiwon Lee
Hee-Pyoung Park
Mu-Hui Jeong
Hyun-Chang Kim
Publication date
01-12-2017
Publisher
Springer Japan
Published in
Journal of Anesthesia / Issue 6/2017
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-017-2411-6

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