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Published in: Journal of Gastroenterology 7/2009

01-07-2009 | Rapid Communication

Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma

Authors: Masato Narita, Etsuro Hatano, Shigeki Arizono, Aya Miyagawa-Hayashino, Hiroyoshi Isoda, Koji Kitamura, Kojiro Taura, Kentaro Yasuchika, Takashi Nitta, Iwao Ikai, Shinji Uemoto

Published in: Journal of Gastroenterology | Issue 7/2009

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Abstract

Background

Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC).

Methods

A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined.

Results

Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r = 0.91, P < 0.0001).

Conclusions

Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.
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Metadata
Title
Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
Authors
Masato Narita
Etsuro Hatano
Shigeki Arizono
Aya Miyagawa-Hayashino
Hiroyoshi Isoda
Koji Kitamura
Kojiro Taura
Kentaro Yasuchika
Takashi Nitta
Iwao Ikai
Shinji Uemoto
Publication date
01-07-2009
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 7/2009
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-009-0056-4

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