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Supportive Care in Cancer

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01-11-2018 | Original Article

Neuropsychological profiles of breast cancer and brain tumor cohorts in Northeast Ontario, Canada

Authors: Matias Mariani, Mark William Glister Collins

Published in: Supportive Care in Cancer | Issue 11/2018

Abstract

Purpose

As developments in cancer treatment have improved outcomes, research has increasingly focused on the role of cancer-related cognitive impairment (CRCI) in quality of life for cancer survivors. Impairment profiles have been heterogeneous across studies, necessitating the study of these effects across different cohorts. The purpose of this preliminary study is to compare the memory profiles of Northeast Ontario breast and CNS cancer patients, as there is no literature which exists for profiling CRCI within this largely rural region.

Methods

Sixty-three outpatients with breast cancer (n = 32) or CNS tumors (n = 30) at the Northeast Cancer Centre in Sudbury, Canada, were administered a neuropsychological test battery as part of their clinical examination. Domains measured within this study included attention and concentration, processing speed, motor function, language skills, verbal and visual memory, and executive functioning.

Results

Participants with brain tumors scored poorer on most neuropsychological measures than participants with breast cancer. Initial verbal memory for individuals with breast cancer was lower than delayed recall and recognition trials. Trial 1 performance for this group was also negatively correlated with self-reported anxiety scores.

Conclusions

Consistent with the literature, participants with breast cancer obtained higher scores on most test measures than participants with CNC tumors. Breast cancer participants had lower verbal memory scores on initial trials compared to delayed recall, potentially due to relationships with anxiety and attention. Further research into this cohort will strive to gain greater understanding of the patterns of deficits experienced and how these may inform individuals with cancer in other regions.

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Title: Neuropsychological profiles of breast cancer and brain tumor cohorts in Northeast Ontario, Canada
Authors: Matias Mariani
Mark William Glister Collins
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 11/2018
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4247-5

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Abstract

Purpose

Methods

Results

Conclusions

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