Skip to main content
Top
Published in: Supportive Care in Cancer 3/2017

Open Access 01-03-2017 | Original Article

Short- and long-term use of medication for psychological distress after the diagnosis of cancer

Authors: Cheng-Hsu Wang, Lynn Chu Huang, Chen-Chang Yang, Chi-Liang Chen, Yiing-Jenq Chou, Yen-Yuan Chen, Wei-Chih Yang, Likwang Chen

Published in: Supportive Care in Cancer | Issue 3/2017

Login to get access

Abstract

Purpose

This study investigated the short- and long-term use of medication for psychological distress after the diagnosis of cancer.

Methods

Longitudinal data from the Taiwan National Health Insurance database were used to follow 35,137 cancer patients for 2.5 years after being diagnosed in 2006 and 2007.

Results

Among those patients who survived for at least 180 days, 20.9 % had used psychotropic medications; sedatives were the most frequently prescribed (14.3 %), followed by antidepressants (5.5 %), anxiolytics (3.6 %), and antipsychotics (2.7 %). Lung cancer, prostate cancer, and oral cancer showed a significant association with the regular use of medication in the first 180 days. Among patients who survived for at least 2.5 years, 4.8 % still used psychotropic medication on a regular basis. Lung cancer and prostate cancer were associated with such prolonged use.

Conclusions

This longitudinal study found that the type of cancer was significantly associated with the use of psychotropic drugs after the diagnosis was made. It provided information about the trajectory of that use and found that a small number of patients were still using those medications after 2.5 years.
Appendix
Available only for authorised users
Literature
1.
go back to reference Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer 94:153–156CrossRefPubMed Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer 94:153–156CrossRefPubMed
2.
go back to reference Keller M, Sommerfeldt S, Fischer C et al (2004) Recognition of distress and psychiatric morbidity in cancer patients: a multi-method approach. Ann Oncol 15:1243–1249CrossRefPubMed Keller M, Sommerfeldt S, Fischer C et al (2004) Recognition of distress and psychiatric morbidity in cancer patients: a multi-method approach. Ann Oncol 15:1243–1249CrossRefPubMed
3.
go back to reference Zabora J, Brintzenhofeszoc K, Curbow B, Hooker C, Piantadosi S (2001) The prevalence of psychological distress by cancer site. Psychooncology 10:19–28CrossRefPubMed Zabora J, Brintzenhofeszoc K, Curbow B, Hooker C, Piantadosi S (2001) The prevalence of psychological distress by cancer site. Psychooncology 10:19–28CrossRefPubMed
4.
go back to reference Braun IM, Rao SR, Pirl WF (2012) Comparison of self-reported cognitive difficulties in a national sample of long-term cancer survivirs and cancer-naïve controls. Psychosomatics 53:68–74CrossRefPubMed Braun IM, Rao SR, Pirl WF (2012) Comparison of self-reported cognitive difficulties in a national sample of long-term cancer survivirs and cancer-naïve controls. Psychosomatics 53:68–74CrossRefPubMed
5.
go back to reference Ng CG, Boks MP, Smeets HM, Zainal NZ, deWit NJ (2009) Prescription patterns for psychotropic drugs in cancer patients: a large population study in the Netherlands. Psychooncology 22:762–767CrossRef Ng CG, Boks MP, Smeets HM, Zainal NZ, deWit NJ (2009) Prescription patterns for psychotropic drugs in cancer patients: a large population study in the Netherlands. Psychooncology 22:762–767CrossRef
6.
go back to reference Hoffman KE, McCarthy EP, Recklitis CJ, Ng AK (2009) Psychological distress in long-term survivors of adult-onset cancer: results from a national survey. Arch Intern Med 169:1274–1281CrossRefPubMed Hoffman KE, McCarthy EP, Recklitis CJ, Ng AK (2009) Psychological distress in long-term survivors of adult-onset cancer: results from a national survey. Arch Intern Med 169:1274–1281CrossRefPubMed
7.
go back to reference Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M (2010) It’s not over when it’s over:long-term symptoms in cancer survivors—a systematic review. Int J Psychiatry Med 40:163–181CrossRefPubMed Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M (2010) It’s not over when it’s over:long-term symptoms in cancer survivors—a systematic review. Int J Psychiatry Med 40:163–181CrossRefPubMed
8.
go back to reference Greer JA, Solis JM, Temel JS et al (2012) Anxiety disorders in long-term survivors of adult cancers. Psychosomatics 53:68–74CrossRef Greer JA, Solis JM, Temel JS et al (2012) Anxiety disorders in long-term survivors of adult cancers. Psychosomatics 53:68–74CrossRef
9.
go back to reference Braun IM, Rao SR, Meyer FL, Fedele G (2015) Patterns of psychiatric medication use among nationally representative long-term cancer survivors and controls. Cancer 121:132–138CrossRefPubMed Braun IM, Rao SR, Meyer FL, Fedele G (2015) Patterns of psychiatric medication use among nationally representative long-term cancer survivors and controls. Cancer 121:132–138CrossRefPubMed
10.
go back to reference Harrison SE, Watson EK, Ward AM et al (2011) Primary health and supportice care needs of long-term cancer survivors; a questionnaire survey. J Clin Oncol 29:2091–2098CrossRefPubMed Harrison SE, Watson EK, Ward AM et al (2011) Primary health and supportice care needs of long-term cancer survivors; a questionnaire survey. J Clin Oncol 29:2091–2098CrossRefPubMed
11.
go back to reference Williams S, Dale J (2006) The effectiveness of treatment for depression/depressive symptoms in adults with cancer: a systematic review. Br J Cancer 94:372–390CrossRefPubMedPubMedCentral Williams S, Dale J (2006) The effectiveness of treatment for depression/depressive symptoms in adults with cancer: a systematic review. Br J Cancer 94:372–390CrossRefPubMedPubMedCentral
12.
go back to reference Rodin G, Lloyd N, Katz M et al (2007) The treatment of depression in cancer patients: a systematic review. Support Care Cancer 15:123–136CrossRefPubMed Rodin G, Lloyd N, Katz M et al (2007) The treatment of depression in cancer patients: a systematic review. Support Care Cancer 15:123–136CrossRefPubMed
13.
go back to reference Lund LW, Winther JF, Cederkvist L et al (2015) Increased risk of antidepressant use in childhood cancer survivors: a Danish population-based cohort study. Eur J Cancer 51:674–684CrossRef Lund LW, Winther JF, Cederkvist L et al (2015) Increased risk of antidepressant use in childhood cancer survivors: a Danish population-based cohort study. Eur J Cancer 51:674–684CrossRef
14.
go back to reference Derogatis LR, Feldstein M, Morrow G et al (1979) A survey of psychotropic drug prescriptions in an oncology population. Cancer 44:1919–1929CrossRefPubMed Derogatis LR, Feldstein M, Morrow G et al (1979) A survey of psychotropic drug prescriptions in an oncology population. Cancer 44:1919–1929CrossRefPubMed
15.
18.
go back to reference Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM (2008) The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract 62:76–87CrossRefPubMedPubMedCentral Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM (2008) The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract 62:76–87CrossRefPubMedPubMedCentral
19.
go back to reference Sikka R, Xia F, Aubert RE (2005) Estimating medication persistency using administrative claims data. Am J Manag Care 11:449–457PubMed Sikka R, Xia F, Aubert RE (2005) Estimating medication persistency using administrative claims data. Am J Manag Care 11:449–457PubMed
20.
go back to reference Conlin PR, Gerth WC, Fox J, Roehm JB, Boccuzzi SJ (2001) Four-year persistence patterns among patients initiating therapy with the angiotensin II receptor antagonist losartan versus other antihypertensive drug classes. Clin Ther 23:1999–2010CrossRefPubMed Conlin PR, Gerth WC, Fox J, Roehm JB, Boccuzzi SJ (2001) Four-year persistence patterns among patients initiating therapy with the angiotensin II receptor antagonist losartan versus other antihypertensive drug classes. Clin Ther 23:1999–2010CrossRefPubMed
21.
go back to reference Chong WW, Aslani P, Chen TF (2011) Effectiveness of interventions to improve antidepressant medication adherence: a systematic review. Int J Clin Pract 65:954–975CrossRefPubMed Chong WW, Aslani P, Chen TF (2011) Effectiveness of interventions to improve antidepressant medication adherence: a systematic review. Int J Clin Pract 65:954–975CrossRefPubMed
22.
go back to reference Soares M, Salluh JI, Ferreira CG, Luiz RR, Spector N, Rocco JR (2005) Impact of two different comorbidity measures on the 6-month mortality of critically ill cancer patients. Intensive Care Med 31:408–415CrossRefPubMed Soares M, Salluh JI, Ferreira CG, Luiz RR, Spector N, Rocco JR (2005) Impact of two different comorbidity measures on the 6-month mortality of critically ill cancer patients. Intensive Care Med 31:408–415CrossRefPubMed
23.
go back to reference Li L-A (2004) A study on the order of the degree of urbanisation among the Lo Chi-Hon Strata of Taiwan counties. Surv Res Method Appl 15:5–30 Li L-A (2004) A study on the order of the degree of urbanisation among the Lo Chi-Hon Strata of Taiwan counties. Surv Res Method Appl 15:5–30
24.
go back to reference Wang GL, Hsu SH, Feng AC et al (2011) The HADS and the DT for screening psychosocial distress of cancer patients in Taiwan. Psychooncology 20:639–646CrossRefPubMed Wang GL, Hsu SH, Feng AC et al (2011) The HADS and the DT for screening psychosocial distress of cancer patients in Taiwan. Psychooncology 20:639–646CrossRefPubMed
25.
go back to reference Lam WW, Chan M, Ka HW, Fielding R (2007) Treatment decision difficulties and post-operative distress predict persistence of psychological morbidity in Chinese women following breast cancer surgery. Psychooncology 16:904–912CrossRefPubMed Lam WW, Chan M, Ka HW, Fielding R (2007) Treatment decision difficulties and post-operative distress predict persistence of psychological morbidity in Chinese women following breast cancer surgery. Psychooncology 16:904–912CrossRefPubMed
26.
go back to reference Mosher CE, Duhamel KN (2012) An examination of distress, sleep, and fatigue in metastatic breast cancer patients. Psychooncology 21:100–107CrossRefPubMed Mosher CE, Duhamel KN (2012) An examination of distress, sleep, and fatigue in metastatic breast cancer patients. Psychooncology 21:100–107CrossRefPubMed
27.
go back to reference Palesh OG, Roscoe JA, Mustian KM et al (2010) Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program. J Clin Oncol 28:292–298CrossRefPubMed Palesh OG, Roscoe JA, Mustian KM et al (2010) Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program. J Clin Oncol 28:292–298CrossRefPubMed
28.
go back to reference Uchitomi Y, Mikami I, Nagai K, Nishiwaki Y, Akechi T, Okamura H (2003) Depression and psychological distress in patients during the year after curative resection of non-small-cell lung cancer. J Clin Oncol 21:69–77CrossRefPubMed Uchitomi Y, Mikami I, Nagai K, Nishiwaki Y, Akechi T, Okamura H (2003) Depression and psychological distress in patients during the year after curative resection of non-small-cell lung cancer. J Clin Oncol 21:69–77CrossRefPubMed
29.
go back to reference Epstein JF, Induni M, Wilson T (2009) Patterns of clinically significant symtoms of depression among heavy users of alcohol and cigarettes. Prev Chronic Dis 6:A09PubMed Epstein JF, Induni M, Wilson T (2009) Patterns of clinically significant symtoms of depression among heavy users of alcohol and cigarettes. Prev Chronic Dis 6:A09PubMed
30.
go back to reference Hammerlid E, Ahlner-Elmqvist M, Bjordak K et al (1999) A prospective multicentre study in Sweden and Norway of mental distress and psychiatric morbidity in head and neck cancer patients. Br J Cancer 80(5e6):766e74 Hammerlid E, Ahlner-Elmqvist M, Bjordak K et al (1999) A prospective multicentre study in Sweden and Norway of mental distress and psychiatric morbidity in head and neck cancer patients. Br J Cancer 80(5e6):766e74
31.
go back to reference Dinh KT, Reznor G, Muralidhar V, et al. (2016) Association of androgen deprivation therapy with depression in localized prostate cancer. p.JC0641969. Dinh KT, Reznor G, Muralidhar V, et al. (2016) Association of androgen deprivation therapy with depression in localized prostate cancer. p.JC0641969.
32.
33.
go back to reference Rauma V, Sintonen H, Rasanen JV, Salo JA, Ilonen IK (2015) Long-term cancer survivors have permanently decreased quality of life after surgery. Clin Lung Cancer 16:40–45CrossRefPubMed Rauma V, Sintonen H, Rasanen JV, Salo JA, Ilonen IK (2015) Long-term cancer survivors have permanently decreased quality of life after surgery. Clin Lung Cancer 16:40–45CrossRefPubMed
34.
go back to reference Yang JC, Shih JY, Su WC et al (2012) Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol 13:539–548CrossRefPubMed Yang JC, Shih JY, Su WC et al (2012) Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol 13:539–548CrossRefPubMed
35.
go back to reference Liao WY, Shun SC, Yu CJ, Yang PC, Lai YH (2011) Symptoms, psychological distress, and supportive care needs in lung cancer patients. Support Care Cancer 19:1743–1751CrossRefPubMed Liao WY, Shun SC, Yu CJ, Yang PC, Lai YH (2011) Symptoms, psychological distress, and supportive care needs in lung cancer patients. Support Care Cancer 19:1743–1751CrossRefPubMed
36.
go back to reference Fallowfield L, Ratcliffe D, Jenkins V, Saul J (2001) Psychiatric morbidity and its recognition by doctors in patients with cancer. Br J Cancer 84:1011–1015CrossRefPubMedPubMedCentral Fallowfield L, Ratcliffe D, Jenkins V, Saul J (2001) Psychiatric morbidity and its recognition by doctors in patients with cancer. Br J Cancer 84:1011–1015CrossRefPubMedPubMedCentral
Metadata
Title
Short- and long-term use of medication for psychological distress after the diagnosis of cancer
Authors
Cheng-Hsu Wang
Lynn Chu Huang
Chen-Chang Yang
Chi-Liang Chen
Yiing-Jenq Chou
Yen-Yuan Chen
Wei-Chih Yang
Likwang Chen
Publication date
01-03-2017
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 3/2017
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-016-3456-z

Other articles of this Issue 3/2017

Supportive Care in Cancer 3/2017 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine