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01-03-2017 | Review Article

Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review

Authors: Elaine Barros Ferreira, Christiane Inocêncio Vasques, Rafael Gadia, Raymond Javan Chan, Eliete Neves Silva Guerra, Luis André Mezzomo, Graziela De Luca Canto, Paula Elaine Diniz dos Reis

Published in: Supportive Care in Cancer | Issue 3/2017

Abstract

Purpose

The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis.

Methods

Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis.

Results

Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention.

Conclusions

There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.

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Title: Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review
Authors: Elaine Barros Ferreira
Christiane Inocêncio Vasques
Rafael Gadia
Raymond Javan Chan
Eliete Neves Silva Guerra
Luis André Mezzomo
Graziela De Luca Canto
Paula Elaine Diniz dos Reis
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 3/2017
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-016-3521-7

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