Skip to main content
Top
Published in: Pediatric Nephrology 4/2021

01-04-2021 | Stroke | Educational Review

Hypertension and childhood stroke

Authors: Juan C. Kupferman, Marc B. Lande, Stella Stabouli, Dimitrios I. Zafeiriou, Steven G. Pavlakis

Published in: Pediatric Nephrology | Issue 4/2021

Login to get access

Abstract

Cerebrovascular disease (stroke) is one of the ten leading causes of death in children and adolescents. Multiple etiologies, from arteriopathies to prothrombic states, can cause stroke in youth. In adult stroke, hypertension has been shown to be the single most important modifiable risk factor. Although hypertension has not been strongly identified as a risk factor in childhood stroke to date, there is preliminary evidence that suggests that hypertension may also be associated with stroke in children. In this review, we summarize the literature that may link hypertension to stroke in the young. We have identified a series of barriers and limitations in the fields of pediatric hypertension and pediatric neurology that might explain why hypertension has been overlooked in childhood stroke. We suggest that hypertension may be a relevant risk factor that, alone or in combination with other multiple factors, contributes to the development of stroke in children. Currently, there are no consensus guidelines for the management of post-stroke hypertension in children. Thus, we recommend that blood pressure be assessed carefully in every child presenting with acute stroke in order to better understand the effects of hypertension in the development and the outcome of childhood stroke. We suggest a treatment algorithm to help practitioners manage hypertension after a stroke.
Literature
1.
go back to reference Heron M (2019) Deaths: leading causes for 2017. Natl Vital Stat Rep 68:1–76PubMed Heron M (2019) Deaths: leading causes for 2017. Natl Vital Stat Rep 68:1–76PubMed
2.
go back to reference Kirkham FJ, Prengler M, Hewes DK, Ganesan V (2000) Risk factors for arterial ischemic stroke in children. J Child Neurol 15:299–307CrossRefPubMed Kirkham FJ, Prengler M, Hewes DK, Ganesan V (2000) Risk factors for arterial ischemic stroke in children. J Child Neurol 15:299–307CrossRefPubMed
7.
go back to reference You RX, McNeil JJ, O'Malley HM, Davis SM, Thrift AG, Donnan GA (1997) Risk factors for stroke due to cerebral infarction in young adults. Stroke 28:1913–1918CrossRefPubMed You RX, McNeil JJ, O'Malley HM, Davis SM, Thrift AG, Donnan GA (1997) Risk factors for stroke due to cerebral infarction in young adults. Stroke 28:1913–1918CrossRefPubMed
18.
go back to reference Daniels SR, Lipman MJ, Burke MJ, Loggie JM (1991) The prevalence of retinal vascular abnormalities in children and adolescents with essential hypertension. Am J Ophthalmol 111:205–208CrossRefPubMed Daniels SR, Lipman MJ, Burke MJ, Loggie JM (1991) The prevalence of retinal vascular abnormalities in children and adolescents with essential hypertension. Am J Ophthalmol 111:205–208CrossRefPubMed
20.
24.
go back to reference Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM, Screening SO, Management Of High Blood Pressure In Children (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140(3). https://doi.org/10.1542/peds.2017-1904 Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM, Screening SO, Management Of High Blood Pressure In Children (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140(3). https://​doi.​org/​10.​1542/​peds.​2017-1904
25.
go back to reference National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114(2 Suppl 4th Report):555–576CrossRef National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114(2 Suppl 4th Report):555–576CrossRef
26.
go back to reference Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV, American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism (2013) An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44:2064–2089. https://doi.org/10.1161/STR.0b013e318296aecaCrossRefPubMed Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV, American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism (2013) An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44:2064–2089. https://​doi.​org/​10.​1161/​STR.​0b013e318296aeca​CrossRefPubMed
27.
go back to reference Hales CMCM, Fryar CD, Ogden CL (2017) Prevalence of obesity among adults and youth: United States 2015-2016. NCHS Data Brief 288:1–8 Hales CMCM, Fryar CD, Ogden CL (2017) Prevalence of obesity among adults and youth: United States 2015-2016. NCHS Data Brief 288:1–8
39.
go back to reference Muntner P, Judd SE, McClellan W, Meschia JF, Warnock DG, Howard VJ (2012) Incidence of stroke symptoms among adults with chronic kidney disease: results from the reasons for geographic and racial differences in stroke (REGARDS) study. Nephrol Dial Transplant 27:166–173. https://doi.org/10.1093/ndt/gfr218CrossRefPubMed Muntner P, Judd SE, McClellan W, Meschia JF, Warnock DG, Howard VJ (2012) Incidence of stroke symptoms among adults with chronic kidney disease: results from the reasons for geographic and racial differences in stroke (REGARDS) study. Nephrol Dial Transplant 27:166–173. https://​doi.​org/​10.​1093/​ndt/​gfr218CrossRefPubMed
41.
go back to reference Ferriero DM, Fullerton HJ, Bernard TJ, Billinghurst L, Daniels SR, De Baun MR, de Veber G, Ichord RN, Jordan LC, Massicotte P, Meldau J, Roach ES, Smith ER, American Heart Association Stroke Council and Council on Cardiovascular and Stroke Nursing (2019) Management of Stroke in neonates and children: a scientific statement from the American Heart Association/American Stroke Association. Stroke 50:e51–e96. https://doi.org/10.1161/STR.0000000000000183CrossRefPubMed Ferriero DM, Fullerton HJ, Bernard TJ, Billinghurst L, Daniels SR, De Baun MR, de Veber G, Ichord RN, Jordan LC, Massicotte P, Meldau J, Roach ES, Smith ER, American Heart Association Stroke Council and Council on Cardiovascular and Stroke Nursing (2019) Management of Stroke in neonates and children: a scientific statement from the American Heart Association/American Stroke Association. Stroke 50:e51–e96. https://​doi.​org/​10.​1161/​STR.​0000000000000183​CrossRefPubMed
43.
44.
go back to reference Fullerton HJ, Wu YW, Zhao S, Johnston SC (2003) Risk of stroke in children: ethnic and gender disparities. Neurology 61:189–194CrossRefPubMed Fullerton HJ, Wu YW, Zhao S, Johnston SC (2003) Risk of stroke in children: ethnic and gender disparities. Neurology 61:189–194CrossRefPubMed
46.
go back to reference Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, Invitti C, Litwin M, Mancia G, Pall D, Rascher W, Redon J, Schaefer F, Seeman T, Sinha M, Stabouli S, Webb NJ, Wuhl E, Zanchetti A (2016) 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens 34:1887–1920. https://doi.org/10.1097/HJH.0000000000001039CrossRefPubMed Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, Invitti C, Litwin M, Mancia G, Pall D, Rascher W, Redon J, Schaefer F, Seeman T, Sinha M, Stabouli S, Webb NJ, Wuhl E, Zanchetti A (2016) 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens 34:1887–1920. https://​doi.​org/​10.​1097/​HJH.​0000000000001039​CrossRefPubMed
47.
go back to reference Ram CV (1978) Hypertensive encephalopathy: recognition and management. Arch Intern Med 138:1851–1853CrossRefPubMed Ram CV (1978) Hypertensive encephalopathy: recognition and management. Arch Intern Med 138:1851–1853CrossRefPubMed
48.
go back to reference Pavlakis SG, Frank Y, Chusid R (1999) Hypertensive encephalopathy, reversible occipitoparietal encephalopathy, or reversible posterior leukoencephalopathy: three names for an old syndrome. J Child Neurol 14:277–281CrossRefPubMed Pavlakis SG, Frank Y, Chusid R (1999) Hypertensive encephalopathy, reversible occipitoparietal encephalopathy, or reversible posterior leukoencephalopathy: three names for an old syndrome. J Child Neurol 14:277–281CrossRefPubMed
52.
go back to reference Dagartzikas MI, Sprague K, Carter G, Tobias JD (2002) Cerebrovascular event, dilated cardiomyopathy, and pheochromocytoma. Pediatr Emerg Care 18:33–35CrossRefPubMed Dagartzikas MI, Sprague K, Carter G, Tobias JD (2002) Cerebrovascular event, dilated cardiomyopathy, and pheochromocytoma. Pediatr Emerg Care 18:33–35CrossRefPubMed
56.
go back to reference Awada A, Daif A, Obeid T, Al Rajeh S (1998) Nontraumatic cerebral hemorrhage in the young: a study of 107 cases. J Stroke Cerebrovasc Dis 7:200–204CrossRefPubMed Awada A, Daif A, Obeid T, Al Rajeh S (1998) Nontraumatic cerebral hemorrhage in the young: a study of 107 cases. J Stroke Cerebrovasc Dis 7:200–204CrossRefPubMed
57.
go back to reference Pellock JM, Kleinman PK, McDonald BM, Wixson D (1980) Childhood hypertensive stroke with neurofibromatosis. Neurology 30:656–659CrossRefPubMed Pellock JM, Kleinman PK, McDonald BM, Wixson D (1980) Childhood hypertensive stroke with neurofibromatosis. Neurology 30:656–659CrossRefPubMed
58.
go back to reference Wheeler PG, Medina S, Dusick A, Bull MJ, Andreoli SP, Edwards-Brown M, Weaver DD (1998) Livedo reticularis, developmental delay and stroke-like episode in a 7-year-old male. Clin Dysmorphol 7:69–74CrossRefPubMed Wheeler PG, Medina S, Dusick A, Bull MJ, Andreoli SP, Edwards-Brown M, Weaver DD (1998) Livedo reticularis, developmental delay and stroke-like episode in a 7-year-old male. Clin Dysmorphol 7:69–74CrossRefPubMed
63.
go back to reference Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, Wethers DL, Pegelow CH, Gill FM (1998) Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 91:288–294PubMed Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, Wethers DL, Pegelow CH, Gill FM (1998) Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 91:288–294PubMed
64.
go back to reference Chung B, Wong V (2004) Pediatric stroke among Hong Kong Chinese subjects. Pediatrics 114:e206–e212CrossRefPubMed Chung B, Wong V (2004) Pediatric stroke among Hong Kong Chinese subjects. Pediatrics 114:e206–e212CrossRefPubMed
66.
go back to reference Van YH, Wang HS, Lai CH, Lin JN, Lo FS (2002) Pheochromocytoma presenting as stroke in two Taiwanese children. J Pediatr Endocrinol Metab 15:1563–1567CrossRefPubMed Van YH, Wang HS, Lai CH, Lin JN, Lo FS (2002) Pheochromocytoma presenting as stroke in two Taiwanese children. J Pediatr Endocrinol Metab 15:1563–1567CrossRefPubMed
77.
go back to reference Ganesan V, Chong WK, Cox TC, Chawda SJ, Prengler M, Kirkham FJ (2002) Posterior circulation stroke in childhood: risk factors and recurrence. Neurology 59:1552–1556CrossRefPubMed Ganesan V, Chong WK, Cox TC, Chawda SJ, Prengler M, Kirkham FJ (2002) Posterior circulation stroke in childhood: risk factors and recurrence. Neurology 59:1552–1556CrossRefPubMed
84.
go back to reference Meyer-Heim AD, Boltshauser E (2003) Spontaneous intracranial haemorrhage in children: aetiology, presentation and outcome. Brain and Development 25:416–421CrossRefPubMed Meyer-Heim AD, Boltshauser E (2003) Spontaneous intracranial haemorrhage in children: aetiology, presentation and outcome. Brain and Development 25:416–421CrossRefPubMed
91.
go back to reference George MG, Tong X, Wigington C, Gillespie C, Hong Y, Centers for Disease C, Prevention (2014) Hypertension screening in children and adolescents--National Ambulatory Medical Care Survey, National Hospital Ambulatory Medical Care Survey, and Medical Expenditure Panel Survey, United States, 2007-2010. MMWR Surveill Summ 63 Suppl 2:47–53 George MG, Tong X, Wigington C, Gillespie C, Hong Y, Centers for Disease C, Prevention (2014) Hypertension screening in children and adolescents--National Ambulatory Medical Care Survey, National Hospital Ambulatory Medical Care Survey, and Medical Expenditure Panel Survey, United States, 2007-2010. MMWR Surveill Summ 63 Suppl 2:47–53
101.
go back to reference Pegelow CH, Colangelo L, Steinberg M, Wright EC, Smith J, Phillips G, Vichinsky E (1997) Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia. Am J Med 102:171–177CrossRefPubMed Pegelow CH, Colangelo L, Steinberg M, Wright EC, Smith J, Phillips G, Vichinsky E (1997) Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia. Am J Med 102:171–177CrossRefPubMed
102.
go back to reference DeBaun MR, Sarnaik SA, Rodeghier MJ, Minniti CP, Howard TH, Iyer RV, Inusa B, Telfer PT, Kirby-Allen M, Quinn CT, Bernaudin F, Airewele G, Woods GM, Panepinto JA, Fuh B, Kwiatkowski JK, King AA, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Sabio H, Gonzalez CE, Saccente SL, Kalinyak KA, Strouse JJ, Fixler JM, Gordon MO, Miller JP, Noetzel MJ, Ichord RN, Casella JF (2012) Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood 119:3684–3690. https://doi.org/10.1182/blood-2011-05-349621CrossRefPubMedPubMedCentral DeBaun MR, Sarnaik SA, Rodeghier MJ, Minniti CP, Howard TH, Iyer RV, Inusa B, Telfer PT, Kirby-Allen M, Quinn CT, Bernaudin F, Airewele G, Woods GM, Panepinto JA, Fuh B, Kwiatkowski JK, King AA, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Sabio H, Gonzalez CE, Saccente SL, Kalinyak KA, Strouse JJ, Fixler JM, Gordon MO, Miller JP, Noetzel MJ, Ichord RN, Casella JF (2012) Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood 119:3684–3690. https://​doi.​org/​10.​1182/​blood-2011-05-349621CrossRefPubMedPubMedCentral
104.
111.
go back to reference Choi Y, Kang BC, Kim KJ, Cheong HI, Hwang YS, Wang KC, Kim IO (1997) Renovascular hypertension in children with moyamoya disease. J Pediatr 131:258–263CrossRefPubMed Choi Y, Kang BC, Kim KJ, Cheong HI, Hwang YS, Wang KC, Kim IO (1997) Renovascular hypertension in children with moyamoya disease. J Pediatr 131:258–263CrossRefPubMed
112.
go back to reference Yamada I, Himeno Y, Matsushima Y, Shibuya H (2000) Renal artery lesions in patients with moyamoya disease: angiographic findings. Stroke 31:733–737CrossRefPubMed Yamada I, Himeno Y, Matsushima Y, Shibuya H (2000) Renal artery lesions in patients with moyamoya disease: angiographic findings. Stroke 31:733–737CrossRefPubMed
119.
go back to reference Roach ES, Golomb MR, Adams R, Biller J, Daniels S, Deveber G, Ferriero D, Jones BV, Kirkham FJ, Scott RM, Smith ER, American Heart Association Stroke Council, Council on Cardiovascular Disease in the Young (2008) Management of stroke in infants and children: a scientific statement from a special writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 39:2644–2691. https://doi.org/10.1161/STROKEAHA.108.189696CrossRefPubMed Roach ES, Golomb MR, Adams R, Biller J, Daniels S, Deveber G, Ferriero D, Jones BV, Kirkham FJ, Scott RM, Smith ER, American Heart Association Stroke Council, Council on Cardiovascular Disease in the Young (2008) Management of stroke in infants and children: a scientific statement from a special writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 39:2644–2691. https://​doi.​org/​10.​1161/​STROKEAHA.​108.​189696CrossRefPubMed
120.
go back to reference Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I; Authors/Task Force Members (2018) 2018 ESC/ESH guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens 36:1953–2041. https://doi.org/10.1097/HJH.0000000000001940 Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I; Authors/Task Force Members (2018) 2018 ESC/ESH guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens 36:1953–2041. https://​doi.​org/​10.​1097/​HJH.​0000000000001940​
121.
go back to reference Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA Sr, Williamson JD, Wright JT Jr (2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive Summary: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Circulation 138:e426–e483. https://doi.org/10.1161/CIR.0000000000000597CrossRefPubMed Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA Sr, Williamson JD, Wright JT Jr (2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive Summary: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Circulation 138:e426–e483. https://​doi.​org/​10.​1161/​CIR.​0000000000000597​CrossRefPubMed
Metadata
Title
Hypertension and childhood stroke
Authors
Juan C. Kupferman
Marc B. Lande
Stella Stabouli
Dimitrios I. Zafeiriou
Steven G. Pavlakis
Publication date
01-04-2021
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 4/2021
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-020-04550-2

Other articles of this Issue 4/2021

Pediatric Nephrology 4/2021 Go to the issue