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Pediatric Nephrology

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01-01-2013 | Original Article

Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study

Authors: Ibrahim F. Shatat, Sherron M. Jakson, Amanda E. Blue, Mary A. Johnson, John K. Orak, Ram Kalpatthi

Published in: Pediatric Nephrology | Issue 1/2013

Abstract

Background

The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD).

Methods

Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected.

Results

Median age was 13 years (range 11–16), body mass index (BMI) 19.1 kg/m² (range 18.2–21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38, P = 0.02).

Conclusion

Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP.

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Title: Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study
Authors: Ibrahim F. Shatat
Sherron M. Jakson
Amanda E. Blue
Mary A. Johnson
John K. Orak
Ram Kalpatthi
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 1/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2275-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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