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Pediatric Nephrology
Published in: Pediatric Nephrology 5/2018

01-05-2018 | Educational Review

Muscle wasting in chronic kidney disease

Authors: Eduardo A. Oliveira, Wai W. Cheung, Kalodiah G. Toma, Robert H. Mak

Published in: Pediatric Nephrology | Issue 5/2018

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Abstract

Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death. Children with CKD have many risk factors for lean mass and muscle wasting, including poor appetite, inflammation, growth hormone resistance, and metabolic acidosis. Mortality risks in patients with CKD increases as body mass index (BMI) and weight decreases. However, data regarding cachexia/PEW and muscle wasting in children with CKD is scarce due to lack of consensus in diagnostic criteria and an appropriate investigative methodology. Further research is urgently needed to address this important complication in the pediatric CKD setting, which may have fundamental impact on clinical outcomes.
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Metadata
Title
Muscle wasting in chronic kidney disease
Authors
Eduardo A. Oliveira
Wai W. Cheung
Kalodiah G. Toma
Robert H. Mak
Publication date
01-05-2018
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 5/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-017-3684-6

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