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01-05-2018 | Original Article

Evaluation of the level of dynamic thiol/disulphide homeostasis in adolescent patients with newly diagnosed primary hypertension

Authors: Evrim Kargın Çakıcı, Fehime Kara Eroğlu, Fatma Yazılıtaş, Mehmet Bülbül, Gökçe Gür, Özlem Aydoğ, Tülin Güngör, Özcan Erel, Murat Alışık, Atilla Halil Elhan

Published in: Pediatric Nephrology | Issue 5/2018

Abstract

Background

Thiol/disulphide homeostasis plays a critical role in numerous intracellular enzymatic pathways including antioxidant defense and detoxification. This study was designed to investigate the impact of thiol/disulfide homeostasis in adolescent patients with recently diagnosed primary hypertension (HT) using a novel and automated method.

Methods

Native thiol/disulphide levels were measured by a novel spectrophotometric method (Cobasc 501, Roche Diagnostics, Mannheim, Germany) in 30 patients with primary HT together with 30 healthy controls.

Results

The levels of native thiol, total thiol, and native thiol/total thiol ratios were significantly lower, while the disulphide level, disulphide/native thiol, and disulphide/total thiol ratios were significantly higher in patients with primary HT compared with the control group. There were significant positive correlations between 24-h mean systolic and diastolic blood pressure and disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios. A multiple linear regression model showed that a disulphide/native thiol ratio above 5 and family history of HT are independent predictors of HT.

Conclusions

Our study showed that dynamic thiol/disulphide homeostasis shifted towards disulphide formation in adolescent patients with primary HT. Understanding the role of thiol/disulfide homeostasis in primary HT might provide new therapeutic intervention strategies for patients.

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Title: Evaluation of the level of dynamic thiol/disulphide homeostasis in adolescent patients with newly diagnosed primary hypertension
Authors: Evrim Kargın Çakıcı
Fehime Kara Eroğlu
Fatma Yazılıtaş
Mehmet Bülbül
Gökçe Gür
Özlem Aydoğ
Tülin Güngör
Özcan Erel
Murat Alışık
Atilla Halil Elhan
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 5/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-017-3865-3

At a glance: The STEP trials

Springer Medicine

Evaluation of the level of dynamic thiol/disulphide homeostasis in adolescent patients with newly diagnosed primary hypertension

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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