Top

Published in:

01-08-2017 | Editorial Commentary

Acute kidney injury in children with sickle cell disease—compounding a chronic problem

Authors: Cherry Mammen, Mei Lin Bissonnette, Douglas G. Matsell

Published in: Pediatric Nephrology | Issue 8/2017

Abstract

In an article recently published in Pediatric Nephrology, Baddam and colleagues discuss the relatively underreported clinical problem of repeated episodes of acute kidney injury (AKI) in children with sickle cell disease (SCD). Their report is a cautionary note about the importance of repeated kidney injury on the background of underlying chronic kidney injury and its potential implications on long-term kidney outcome. In children and adults with SCD, this includes the effects of repeated vaso-occlusive crises and the management of these painful episodes with non-steroidal anti-inflammatory drugs. Here we review the scope of kidney involvement in SCD in children and discuss the potential short- and long-term consequences of AKI in children with SCD.

Baddam S, Aban I, Hilliard L, Howard T, Askenazi D, Lebensburger JD (2017) Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis. Pediatr Nephrol. doi:10.1007/s00467-017-3623-6 PubMed

Lebensburger JD, Palabindela P, Howard TH, Feig DI, Aban I, Askenazi DJ (2016) Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome. Pediatr Nephrol 31:1363–1368CrossRefPubMed

Audard V, Homs S, Habibi A, Galacteros F, Bartolucci P, Godeau B, Renaud B, Levy Y, Grimbert P, Lang P, Brun-Buisson C, Brochard L, Schortgen F, Maitre B, Mekontso Dessap A (2010) Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and its relation to pulmonary hypertension. Nephrol Dial Transplant 25:2524–2529CrossRefPubMed

Sklar AH, Perez JC, Harp RJ, Caruana RJ (1990) Acute renal failure in sickle cell anemia. Int J Artif Organs 13:347–351PubMed

Wesson DE (2002) The initiation and progression of sickle cell nephropathy. Kidney Int 61:2277–2286CrossRefPubMed

Statius van Eps LW, Pinedo-Veels C, de Vries GH, de Koning J (1970) Nature of concentrating defect in sickle-cell nephropathy. Microradioangiographic studies Lancet 1:450–452CrossRefPubMed

Bissonnette ML, Henriksen KJ, Delaney K, Stankus N, Chang A (2016) Medullary Microvascular thrombosis and injury in sickle hemoglobin C disease. J Am Soc Nephrol 27:1300–1304CrossRefPubMed

Nath KA, Hebbel RP (2015) Sickle cell disease: renal manifestations and mechanisms. Nat Rev Nephrol 11:161–171CrossRefPubMedPubMedCentral

Silva Junior GB, Liborio AB, Vieira AP, Bem AX, Lopes Filho AS, Figueiredo Filho AC, Guedes AL, Souza JH, Costa CM, Costa R, Daher EF (2012) Evaluation of renal function in sickle cell disease patients in Brazil. Braz J Med Biol Res 45:652–655CrossRefPubMedPubMedCentral

10.

Guasch A, Navarrete J, Nass K, Zayas CF (2006) Glomerular involvement in adults with sickle cell hemoglobinopathies: prevalence and clinical correlates of progressive renal failure. J Am Soc Nephrol 17:2228–2235CrossRefPubMed

11.

Gosmanova EO, Zaidi S, Wan JY, Adams-Graves PE (2014) Prevalence and progression of chronic kidney disease in adult patients with sickle cell disease. J Investig Med 62:804–807CrossRefPubMed

12.

Powars DR, Elliott-Mills DD, Chan L, Niland J, Hiti AL, Opas LM, Johnson C (1991) Chronic renal failure in sickle cell disease: risk factors, clinical course, and mortality. Ann Intern Med 115:614–620CrossRefPubMed

13.

Powars DR, Chan LS, Hiti A, Ramicone E, Johnson C (2005) Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients. Medicine 84:363–376CrossRefPubMed

14.

Abbott KC, Hypolite IO, Agodoa LY (2002) Sickle cell nephropathy at end-stage renal disease in the United States: patient characteristics and survival. Clin Nephrol 58:9–15CrossRefPubMed

15.

Etteldorf JN, Tuttle AW, Clayton GW (1952) Renal function studies in pediatrics. 1. Renal hemodynamics in children with sickle cell anemia. Am J Dis Child 83:185–191

16.

Ware RE, Rees RC, Sarnaik SA, Iyer RV, Alvarez OA, Casella JF, Shulkin BL, Shalaby-Rana E, Strife CF, Miller JH, Lane PA, Wang WC, Miller ST, Investigators BABYHUG (2010) Renal function in infants with sickle cell anemia: baseline data from the BABY HUG trial. J Pediatr 156:66–70CrossRefPubMedPubMedCentral

17.

Alvarez O, Miller ST, Wang WC, Luo Z, McCarville MB, Schwartz GJ, Thompson B, Howard T, Iyer RV, Rana SR, Rogers ZR, Sarnaik SA, Thornburg CD, Ware RE, Investigators BABYHUG (2012) Effect of hydroxyurea treatment on renal function parameters: results from the multi-center placebo-controlled BABY HUG clinical trial for infants with sickle cell anemia. Pediatr Blood Cancer 59:668–674CrossRefPubMedPubMedCentral

18.

Becker AM (2011) Sickle cell nephropathy: challenging the conventional wisdom. Pediatr Nephrol 26:2099–2109CrossRefPubMed

19.

Piepsz A, Tondeur M, Ham H (2006) Revisiting normal (51)Cr-ethylenediaminetetraacetic acid clearance values in children. Eur J Nucl Med Mol Imaging 33:1477–1482CrossRefPubMed

20.

Alvarez O, Montane B, Lopez G, Wilkinson J, Miller T (2006) Early blood transfusions protect against microalbuminuria in children with sickle cell disease. Pediatr Blood Cancer 47:71–76CrossRefPubMed

21.

Dharnidharka VR, Dabbagh S, Atiyeh B, Simpson P, Sarnaik S (1998) Prevalence of microalbuminuria in children with sickle cell disease. Pediatr Nephrol 12:475–478CrossRefPubMed

22.

McPherson Yee M, Jabbar SF, Osunkwo I, Clement L, Lane PA, Eckman JR, Guasch A (2011) Chronic kidney disease and albuminuria in children with sickle cell disease. Clin J Am Soc Nephrol 6:2628–2633CrossRefPubMedPubMedCentral

23.

Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629–637CrossRefPubMedPubMedCentral

24.

Bodas P, Huang A, O’Riordan MA, Sedor JR, Dell KM (2013) The prevalence of hypertension and abnormal kidney function in children with sickle cell disease—a cross sectional review. BMC Nephrol 14:237CrossRefPubMedPubMedCentral

25.

Cecchini J, Lionnet F, Djibre M, Parrot A, Stojanovic KS, Girot R, Fartoukh M (2014) Outcomes of adult patients with sickle cell disease admitted to the ICU: a case series. Crit Care Med 42:1629–1639CrossRefPubMed

26.

de Jong PE, de Jong-Van Den Berg TW, Sewrajsingh GS, Schouten H, Donker AJ, Statius van Eps LW (1980) The influence of indomethacin on renal haemodynamics in sickle cell anaemia. Clin Sci 59:245–250CrossRefPubMed

27.

Audard V, Moutereau S, Vandemelebrouck G, Habibi A, Khellaf M, Grimbert P, Levy Y, Loric S, Renaud B, Lang P, Godeau B, Galacteros F, Bartolucci P (2014) First evidence of subclinical renal tubular injury during sickle-cell crisis. Orphanet J Rare Dis 9:67CrossRefPubMedPubMedCentral

28.

de Jong PE, Statius van Eps LW (1985) Sickle cell nephropathy: new insights into its pathophysiology. Kidney Int 27:711–717CrossRefPubMed

29.

Allon M, Lawson L, Eckman JR, Delaney V, Bourke E (1988) Effects of nonsteroidal antiinflammatory drugs on renal function in sickle cell anemia. Kidney Int 34:500–506CrossRefPubMed

30.

Cacciotti C, Vaiselbuh S, Romanos-Sirakis E (2016) Pain Management for Sickle Cell Disease in the pediatric emergency Department: medications and hospitalization trends. Clin Pediatr (Phila). doi:10.1177/0009922816674521

31.

Hardwick WE Jr, Givens TG, Monroe KW, King WD, Lawley D (1999) Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. Pediatr Emerg Care 15:179–182CrossRefPubMed

32.

Balestracci A, Ezquer M, Elmo ME, Molini A, Thorel C, Torrents M, Toledo I (2015) Ibuprofen-associated acute kidney injury in dehydrated children with acute gastroenteritis. Pediatr Nephrol 30:1873–1878CrossRefPubMed

33.

Misurac JM, Knoderer CA, Leiser JD, Nailescu C, Wilson AC, Andreoli SP (2013) Nonsteroidal anti-inflammatory drugs are an important cause of acute kidney injury in children. J Pediatr 162:1153–1159CrossRefPubMed

34.

Coca SG, Singanamala S, Parikh CR (2012) Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int 81:442–448CrossRefPubMed

35.

Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE (2011) The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 79:1361–1369CrossRefPubMedPubMedCentral

36.

Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, Collins AJ (2009) Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 20:223–228CrossRefPubMedPubMedCentral

37.

Thakar CV, Christianson A, Himmelfarb J, Leonard AC (2011) Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol 6:2567–2572CrossRefPubMedPubMedCentral

38.

Mammen C, Al Abbas A, Skippen P, Nadel H, Levine D, Collet JP, Matsell DG (2012) Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study. Am J Kidney Dis 59:523–530CrossRefPubMed

39.

Viaud M, Llanas B, Harambat J (2012) Renal outcome in long-term survivors from severe acute kidney injury in childhood. Pediatr Nephrol 27:151–152, author reply 153CrossRefPubMed

40.

Slack R, Hawkins KC, Gilhooley L, Addison GM, Lewis MA, Webb NJ (2005) Long-term outcome of meningococcal sepsis-associated acute renal failure. Pediatr Crit Care Med 6:477–479CrossRefPubMed

41.

Shaw NJ, Brocklebank JT, Dickinson DF, Wilson N, Walker DR (1991) Long-term outcome for children with acute renal failure following cardiac surgery. Int J Cardiol 31:161–165CrossRefPubMed

42.

Georgaki-Angelaki HN, Steed DB, Chantler C, Haycock GB (1989) Renal function following acute renal failure in childhood: a long term follow-up study. Kidney Int 35:84–89CrossRefPubMed

43.

Askenazi DJ, Feig DI, Graham NM, Hui-Stickle S, Goldstein SL (2006) 3-5 year longitudinal follow-up of pediatric patients after acute renal failure. Kidney Int 69:184–189CrossRefPubMed

44.

Menon S, Kirkendall ES, Nguyen H, Goldstein SL (2014) Acute kidney injury associated with high nephrotoxic medication exposure leads to chronic kidney disease after 6 months. J Pediatr 165:522–527CrossRefPubMed

Title: Acute kidney injury in children with sickle cell disease—compounding a chronic problem
Authors: Cherry Mammen
Mei Lin Bissonnette
Douglas G. Matsell
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2017
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-017-3650-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Acute kidney injury in children with sickle cell disease—compounding a chronic problem

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 8/2017

Toll-like receptor 3 (TLR-3), TLR-4 and CD80 expression in peripheral blood mononuclear cells and urinary CD80 levels in children with idiopathic nephrotic syndrome

Viral load of EBV DNAemia is a predictor of EBV-related post-transplant lymphoproliferative disorders in pediatric renal transplant recipients

Facial swelling in a child on chronic hemodialysis: Questions

The association between creatinine versus cystatin C-based eGFR and cardiovascular risk in children with chronic kidney disease using a modified PDAY risk score

Frequent hemodialysis: history of the modality and assessment of outcomes

Facial swelling in a child on chronic hemodialysis: Answers