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01-08-2016 | Original Article

Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome

Authors: Jeffrey D. Lebensburger, Prasannalaxmi Palabindela, Thomas H. Howard, Daniel I. Feig, Inmaculada Aban, David J. Askenazi

Published in: Pediatric Nephrology | Issue 8/2016

Abstract

Background

Patients with sickle cell disease are at risk for developing chronic kidney disease (CKD). Acute kidney injury (AKI) has been linked to progression to CKD, but limited data exist to determine its role in acute complications of sickle cell disease. We hypothesized that AKI occurs in pediatric patients admitted for acute chest syndrome (ACS) and prolongs hospitalization.

Methods

We conducted a 6-year retrospective review of pediatric patients with ACS admitted to a single medical institution.

Results

Of the 149 pediatric patients admitted for ACS during the 6-year study period, 12 (8 %) developed AKI. Comparison of patients with and without AKI revealed a significant association between AKI and a larger drop in hemoglobin value from baseline (2.7 vs. 1.4 g/dL; p = 0.003), a lower hemoglobin value at admission (6.4 vs. 7.5 g/dL; p = 0.03), and an increased white blood cell count at admission (33.1 vs. 19.8 × 10⁹/L; p < 0.0001), respectively. AKI (p < 0.0001) together with need for advanced respiratory support (biphasic positive airway pressure or mechanical ventilation) (p < 0.0001) and need for exchange transfusion (p < 0.0001) were associated with prolonged hospitalization.

Conclusions

Clinicians should monitor pediatric patients hospitalized for ACS for the development of AKI as a potentially modifiable risk factor for prolonged hospitalization.

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Title: Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome
Authors: Jeffrey D. Lebensburger
Prasannalaxmi Palabindela
Thomas H. Howard
Daniel I. Feig
Inmaculada Aban
David J. Askenazi
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3370-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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