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Pediatric Nephrology

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01-11-2014 | Original Article

Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections

Authors: Hyung Eun Yim, Hyungshin Yim, Eun Soo Bae, Sang Uk Woo, Kee Hwan Yoo

Published in: Pediatric Nephrology | Issue 11/2014

Abstract

Background

Early predictive biomarkers for the diagnosis and management of febrile urinary tract infections (UTIs) can be valuable diagnostic tools in children.

Methods

The study cohort comprised 73 pediatric patients with febrile UTIs [46 with acute pyelonephritis (APN) and 27 with lower UTIs] and 56 healthy children. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1) levels and serum cystatin C (sCysC) levels were measured.

Results

The uNGAL/creatinine (Cr) and uKIM-1/Cr levels were higher in the UTI group than in the controls (P < 0.05). uNGAL/Cr and sCysC levels were higher in patients with APN than in those with lower UTIs (P < 0.05). uNGAL/Cr levels in both the APN and UTI groups decreased following the administration of antibiotics compared to those before treatment (P < 0.05). The uNGAL/Cr level was correlated with serum levels of white blood cells, C-reactive protein, CysC and with uKIM-1/Cr (P < 0.05). uKIM-1/Cr was also correlated with sCysC (P < 0.05). Receiver operating curve analyses showed good diagnostic profiles of uNGAL/Cr and uKIM-1/Cr for identifying UTIs [area under the curve (AUC) 0.9 and 0.66, respectively) and of uNGAL/Cr and sCysC for predicting APN (AUC 0.78 and 0.72, respectively).

Conclusions

Our results suggest that uNGAL, uKIM-1 and sCysC levels may be useful for predicting and managing febrile UTIs in children.

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Title: Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections
Authors: Hyung Eun Yim
Hyungshin Yim
Eun Soo Bae
Sang Uk Woo
Kee Hwan Yoo
Publication date: 01-11-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 11/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2845-0

At a glance: The STEP trials

Springer Medicine

Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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