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Pediatric Nephrology

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Open Access 01-11-2014 | Original Article

Normal values for urine renalase excretion in children

Authors: Agnieszka Rybi–Szumińska, Joanna Michaluk-Skutnik, Barbara Osipiuk-Remża, Anna Kossakowska, Anna Wasilewska

Published in: Pediatric Nephrology | Issue 11/2014

Abstract

Background

The objective of this study was to establish age-dependent values for urinary renalase/creatinine (renalase/Cr) ratio in healthy children and adolescents.

Methods

The study was conducted on a random sample of 157 healthy children and adolescents (0.1–17.9 years) divided into six age groups in 3-year intervals. Urine renalase concentration was measured using an enzyme-linked immunosorbent assay (ELISA) kit (Uscn Life Science, Wuhan, China).

Results

We analyzed median urine renalase/Cr ratio in particular age groups with the use of analysis of variance (ANOVA). Renalase/Cr levels were significantly higher in the youngest children < 3 years in comparison with other age groups (4.07 ng/mg Cr, p < 0.05). There was a statistically significant negative correlation between urine renalase/Cr and body mass index (BMI) Z-score (r = −0.22, p < 0.05) and both systolic (r = −0.22, p < 0.05) and diastolic (r = −0.21, p < 0.05) blood pressure. We constructed the reference renalase/Cr percentiles according to age in 3-year intervals.

Conclusions

To the best of our knowledge, this study is the first to present reference values of urine renalase excretion in a healthy pediatric population. Further studies should concentrate on the influence of increased blood pressure or obesity on urine renalase excretion in children and teenagers.

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Title: Normal values for urine renalase excretion in children
Authors: Agnieszka Rybi–Szumińska
Joanna Michaluk-Skutnik
Barbara Osipiuk-Remża
Anna Kossakowska
Anna Wasilewska
Publication date: 01-11-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 11/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2855-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Normal values for urine renalase excretion in children

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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