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Pediatric Nephrology

Published in:

01-03-2013 | Original Article

Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome

Authors: Ahmet Taner Elmas, Yilmaz Tabel, Özlem Nalbantoğlu Elmas

Published in: Pediatric Nephrology | Issue 3/2013

Abstract

Background

We aimed to compare serum cystatin C levels (sCysC) in preterm neonates with respiratory distress syndrome (RDS) with a control group and to investigate whether it could be used as a predictor for acute kidney injury (AKI).

Methods

sCysC was measured in 62 neonates with RDS (n = 28) and control neonates without RDS (n = 34), whose gestational ages (GA) were between 27 and 29 weeks (subgroup 1) and 30–32 weeks (subgroup 2). AKI was defined as oliguria and/or increase of serum creatinine. Blood samples were obtained on postnatal days (PND) 3 and 30. sCysC levels were determined by particle-enhanced nephelometric immunoassay.

Results

There were six neonates with AKI (RDS-AKI subgroup) and 22 neonates without AKI (RDS-no AKI subgroup) during the first 7 days. Although sCysC levels were lower in neonates with RDS than controls on PND3 in both GA subgroups, the differences were not significant. However, in neonates with RDS and AKI, sCysC levels were significantly higher than neonates with RDS but no AKI and neonates in the control group on PND3. sCysC level was found to have a statistically significant association with AKI development in preterm neonates with RDS.

Conclusions

sCysC is an independent predictor of AKI in preterm neonates with RDS.

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Title: Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome
Authors: Ahmet Taner Elmas
Yilmaz Tabel
Özlem Nalbantoğlu Elmas
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 3/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2331-5

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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