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Pediatric Nephrology
Published in: Pediatric Nephrology 5/2012

Open Access 01-05-2012 | Original Article

Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates

Authors: Yanhong Li, Chenlu Fu, Xiaofei Zhou, Zhihui Xiao, Xueming Zhu, Meifang Jin, Xiaozhong Li, Xing Feng

Published in: Pediatric Nephrology | Issue 5/2012

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Abstract

Background

Urinary interleukin-18 and cystatin-C are suggested to be biomarkers for predicting acute kidney injury (AKI). The aims of this study are to examine whether the urinary concentrations of interleukin-18 and cystatin-C vary with gestational age and other factors in non-AKI control neonates, and to determine whether urinary interleukin-18 and cystatin-C can predict AKI development in non-septic critically ill neonates, independently of potential confounders.

Methods

We enrolled 62 non-septic critically ill neonates. Urine was collected every 48–72 h during the first 10 days of life.

Results

Urinary concentration of cystatin-C, but not interleukin-18, decreased with increasing gestational age and body weight, but not with increasing postnatal age in non-AKI control neonates. Both urinary interleukin-18 and cystatin-C were associated with AKI, even after controlling for gestational and postnatal age, birth weight, gender, Apgar score and the score for neonatal acute physiology in non-septic critically ill neonates. Urinary interleukin-18 and cystatin-C had odds ratios of 2.27 and 2.07, and achieved the area under-the-receiver-operating-characteristic curve of 0.72 and 0.92, respectively, for predicting AKI.

Conclusions

The urinary concentration of cystatin-C, but not interleukin-18, may decrease with increasing renal maturity. Both urinary interleukin-18 and cystatin-C are independently predictive of AKI in non-septic critically ill neonates.

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Metadata
Title
Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates
Authors
Yanhong Li
Chenlu Fu
Xiaofei Zhou
Zhihui Xiao
Xueming Zhu
Meifang Jin
Xiaozhong Li
Xing Feng
Publication date
01-05-2012
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 5/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-011-2072-x

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