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01-04-2011 | Review

A review of 130 humans enrolled in transgastric NOTES protocols at a single institution

Authors: Peter Nau, E. Christopher Ellison, Peter Muscarella Jr., Dean Mikami, Vimal K. Narula, Bradley Needleman, W. Scott Melvin, Jeffrey W. Hazey

Published in: Surgical Endoscopy | Issue 4/2011

Abstract

Background

The methodology of Natural Orifice Translumenal Endoscopic Surgery (NOTES) has been validated in both human and animal models. Herein is a discussion of our experience gained from the initial 130 patients enrolled in transgastric pre-NOTES and NOTES protocols at our institution.

Methods

A retrospective review of our research database was performed for all patients enrolled in NOTES protocols. The infectious risk of a gastrotomy with and without a NOTES procedure was assessed in 100 patients. Eighty patients completed a true NOTES protocol looking at staging, access, and insufflation with select patients evaluating the potential for bacterial contamination of the abdominal compartment.

Results

A total of 130 patients have completed pre-NOTES and NOTES protocols at our institution. We observed no clinically significant contamination of the abdomen secondary to transgastric procedures in 100 patients. Diagnostic transgastric endoscopic peritoneoscopy (DTEP) was completed in 20 patients with pancreatic head masses and found to have a 95% concordance with laparoscopic exploration for assessment of peritoneal metastases. Blind endoscopic gastrotomy and DTEP were evaluated in 40 patients who underwent laparoscopic Roux-en-Y gastric bypass procedures (LSRYGB) and were found to be safe, reliable, and without a clinically significant risk of contamination. Endoscopic peritoneal insufflation was successfully established and correlated with standard laparoscopic insufflation in 20 patients.

Conclusions

Transgastric NOTES is a safe alternative approach to accessing the peritoneal cavity in humans. The risk of bacterial contamination secondary to peroral and transgastric access is clinically insignificant. A device for the facile closure of the gastric defect is the sole factor limiting institution of this methodology as a standalone technique.

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Title: A review of 130 humans enrolled in transgastric NOTES protocols at a single institution
Authors: Peter Nau
E. Christopher Ellison
Peter Muscarella Jr.
Dean Mikami
Vimal K. Narula
Bradley Needleman
W. Scott Melvin
Jeffrey W. Hazey
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 4/2011
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-010-1369-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A review of 130 humans enrolled in transgastric NOTES protocols at a single institution

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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