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Journal of Cancer Research and Clinical Oncology

Published in:

01-01-2021 | Cancer Therapy | Review – Cancer Research

MAPK signaling pathway-targeted marine compounds in cancer therapy

Authors: Jiaen Wei, Ruining Liu, Xiyun Hu, Tingen Liang, Zhiran Zhou, Zunnan Huang

Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2021

Abstract

Purpose

This paper reviews marine compounds that target the mitogen-activated protein kinase (MAPK) signaling pathway and their main sources, chemical structures, major targeted cancers and possible mechanisms to provide comprehensive and basic information for the development of marine compound-based antitumor drugs in clinical cancer therapy research.

Methods

This paper searched the PubMed database using the keywords “cancer”, “marine*” and “MAPK signaling pathway”; this search was supplemented by the literature-tracing method. The marine compounds screened for review in this paper are pure compounds with a chemical structure and have antitumor effects on more than one tumor cell line by targeting the MAPK signaling pathway. The PubChem database was used to search for the PubMed CID and draw the chemical structures of the marine compounds.

Results

A total of 128 studies were searched, and 32 marine compounds with unique structures from extensive sources were collected for this review. These compounds are cytotoxic to cancer cell lines, although their targets are still unclear. This paper describes their anticancer effect mechanisms and the protein expression changes in the MAPK pathway induced by these marine compound treatments. This review is the first to highlight MAPK signaling pathway-targeted marine compounds and their use in cancer therapy.

Conclusion

The MAPK signaling pathway is a promising potential target for cancer therapy. Searching for marine compounds that exert anticancer effects by targeting the MAPK signaling pathway and developing them into new marine anticancer drugs will be beneficial for cancer treatment.

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Title: MAPK signaling pathway-targeted marine compounds in cancer therapy
Authors: Jiaen Wei
Ruining Liu
Xiyun Hu
Tingen Liang
Zhiran Zhou
Zunnan Huang
Publication date: 01-01-2021
Publisher: Springer Berlin Heidelberg
Keyword: Cancer Therapy
Published in: Journal of Cancer Research and Clinical Oncology / Issue 1/2021
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-020-03460-y

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STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

At a glance: The STEP trials

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