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Journal of Cancer Research and Clinical Oncology

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01-03-2018 | Original Article – Clinical Oncology

Analysis of prognostic factors after resection of solitary liver metastasis in colorectal cancer: a 22-year bicentre study

Authors: Sara Acciuffi, Frank Meyer, Astrid Bauschke, Utz Settmacher, Hans Lippert, Roland Croner, Annelore Altendorf-Hofmann

Published in: Journal of Cancer Research and Clinical Oncology | Issue 3/2018

Abstract

Purpose

The investigation of the predictors of outcome after hepatic resection for solitary colorectal liver metastasis.

Methods

We recruited 350 patients with solitary colorectal liver metastasis at the University Hospitals of Jena and Magdeburg, who underwent curative liver resection between 1993 and 2014. All patients had follow-up until death or till summer 2016.

Results

The follow-up data concern 96.6% of observed patients. The 5- and 10-year overall survival rates were 47 and 28%, respectively. The 5- and 10-year disease-free survival rates were 30 and 20%, respectively. The analysis of the prognostic factors revealed that the pT category of primary tumour, size and grade of the metastasis and extension of the liver resection had no statistically significant impact on survival and recurrence rates. In multivariate analysis, age, status of lymph node metastasis at the primary tumour, location of primary tumour, time of appearance of the metastasis, the use of preoperative chemotherapy and the presence of extrahepatic tumour proved to be independent statistically significant predictors for the prognosis. Moreover, patients with rectal cancer had a lower intrahepatic recurrence rate, but a higher extrahepatic recurrence rate.

Conclusion

The long-term follow-up of patients with R0-resected liver metastasis is multifactorially influenced. Age and comorbidity have a role only in the overall survival. More than three lymph node metastasis reduced both the overall and disease-free survival. Extrahepatic tumour had a negative influence on the extrahepatic recurrence and on the overall survival. Neither overall survival nor recurrence rates was improved using neoadjuvant chemotherapy.

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Title: Analysis of prognostic factors after resection of solitary liver metastasis in colorectal cancer: a 22-year bicentre study
Authors: Sara Acciuffi
Frank Meyer
Astrid Bauschke
Utz Settmacher
Hans Lippert
Roland Croner
Annelore Altendorf-Hofmann
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 3/2018
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-018-2583-y

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Analysis of prognostic factors after resection of solitary liver metastasis in colorectal cancer: a 22-year bicentre study

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Methods

Results

Conclusion

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