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Journal of Cancer Research and Clinical Oncology

Published in:

01-01-2017 | Review – Cancer Research

Hyaluronic acid in digestive cancers

Authors: Ruo-Lin Wu, Lei Huang, Hong-Chuan Zhao, Xiao-Ping Geng

Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2017

Abstract

Purpose

Hyaluronan (HA), an extracellular and peri-cellular glycosaminoglycan with a large molecular weight, plays an important role in cancer growth and metastasis. The aim of this study was to summarize the biological roles and regulation of HA and small HA fragments, and their metabolismn enzymes and receptors in human digestive cancers.

Methods

A systematic literature search mainly focusing on the biological roles of HA in the development and progression of human digestive cancers was performed using electronic databases.

Results

The correlation between HA accumulation and tumor progression has been shown in various digestive cancers. HA and HA fragment-tumor cell interaction could activate the downstream signaling pathways, promoting cell proliferation, adhesion, migration and invasion, and inducing angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like property, and chemoradioresistance in digestive cancers.

Conclusions

A better insight into the mechanism of HA and HA fragment involvement in digestive cancer progression might be useful for the development of novel biomarkers and therapeutic strategies.

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Title: Hyaluronic acid in digestive cancers
Authors: Ruo-Lin Wu
Lei Huang
Hong-Chuan Zhao
Xiao-Ping Geng
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 1/2017
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2213-5

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Hyaluronic acid in digestive cancers

Abstract

Purpose

Methods

Results

Conclusions

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