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Published in: Journal of Cancer Research and Clinical Oncology 7/2012

01-07-2012 | Original Paper

Basaloid squamous cell carcinoma of the esophagus

Authors: Shao-Bin Chen, Hong-Rui Weng, Geng Wang, Jie-Sheng Yang, Wei-Ping Yang, Hua Li, Di-Tian Liu, Yu-Ping Chen

Published in: Journal of Cancer Research and Clinical Oncology | Issue 7/2012

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Abstract

Purpose

Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare carcinoma with distinct characteristics. No standard treatment has been established. This retrospective study was designed to investigate the clinical and pathological characteristics, diagnosis, treatment, and prognosis of esophageal BSCC.

Methods

Clinical data were retrospectively analyzed from 26 patients with pathologically confirmed esophageal BSCC who underwent transthoracic esophagectomy with lymphadenectomy between January 1995 and June 2010 at the Cancer Hospital of Shantou University Medical College. Clinicopathologic data between BSCC patients and different histologic grades of esophageal squamous cell carcinoma (ESCC) patients were statistically compared by means of the χ2 test or Fisher’s exact test. The Kaplan–Meier and log-rank methods were used to estimate and compare survival rates.

Results

Microscopically, BSCC was characterized by a nesting, lobular, or trabecular arrangement of small crowded cells with scant cytoplasm. None of the histologic specimens taken at preoperative esophagoscopy were diagnosed as BSCC. The median survival time (MST) of the 26 patients was 29.0 months (95% confidence interval, 9.0–49.0), and the 1-, 3-, and 5-year overall survival rates were 73.1, 42.7, and 36.6%, respectively. The MST for BSCC patients was significantly lower than that of well-differentiated SCC patients (P = 0.024), but there were no significant differences between the MST for BSCC patients and that of moderately or poorly differentiated SCC patients (P > 0.05).

Conclusions

BSCC of the esophagus is a rare but distinctive disease and is prone to be misdiagnosed by endoscopic biopsy. The prognosis is poorer than well-differentiated SCC, but similar to moderately or poorly differentiated SCC.
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Metadata
Title
Basaloid squamous cell carcinoma of the esophagus
Authors
Shao-Bin Chen
Hong-Rui Weng
Geng Wang
Jie-Sheng Yang
Wei-Ping Yang
Hua Li
Di-Tian Liu
Yu-Ping Chen
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Journal of Cancer Research and Clinical Oncology / Issue 7/2012
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-012-1180-8

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