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Journal of Cancer Research and Clinical Oncology

Published in:

01-10-2010 | Original Paper

Overexpression of Galectin-1 is negatively correlated with pathologic differentiation grade in oral squamous cell carcinoma

Authors: Lai-ping Zhong, Kui-jie Wei, Xiao Yang, Hong-ya Pan, Dong-xia Ye, Li-zhen Wang, Zhi-yuan Zhang

Published in: Journal of Cancer Research and Clinical Oncology | Issue 10/2010

Abstract

Purpose

To determine the Galectin-1 protein expression in oral squamous cell carcinoma (OSCC).

Methods

Comparative proteomic analysis of an in vitro cellular carcinogenesis model of OSCC we previously established was performed to identify differentially expressed proteins. Galectin-1 was further validated in vitro (human immortalized oral epithelia cell line and OSCC lines) and in vivo (tissue samples from OSCC patients) by Western blotting and immunohistochemistry, respectively.

Results

Increased Galectin-1 protein expression was identified in the cancerous cell line compared with the immortalized oral epithelial cell line in the in vitro cellular carcinogenesis model, and then validated in the OSCC lines and cancerous tissues. Galectin-1 protein expression was negatively correlated with the tumor pathologic differentiation grades, a higher Galectin-1 protein expression indicating a poorer pathologic differentiation grade.

Conclusions

Galectin-1 protein expression level increases in OSCC, it may serve as a candidate marker for pathologic differentiation grade of OSCC.

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Title: Overexpression of Galectin-1 is negatively correlated with pathologic differentiation grade in oral squamous cell carcinoma
Authors: Lai-ping Zhong
Kui-jie Wei
Xiao Yang
Hong-ya Pan
Dong-xia Ye
Li-zhen Wang
Zhi-yuan Zhang
Publication date: 01-10-2010
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 10/2010
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-010-0810-2

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Overexpression of Galectin-1 is negatively correlated with pathologic differentiation grade in oral squamous cell carcinoma

Abstract

Purpose

Methods

Results

Conclusions

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