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Journal of Cancer Research and Clinical Oncology

Published in:

01-01-2009 | Review

Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors

Authors: Shoshana J. Weiner, Siyamek Neragi-Miandoab

Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2009

Abstract

Background

Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor for which no effective therapy exists despite the discovery of many possible molecular and genetic targets. The late stage of MPM diagnosis and the long latency that exist between some exposures and diagnosis have made it difficult to comprehensively evaluate the role of risk factors and their downstream molecular effects.

Methods

This manuscript is a review of current literature about the pathogenesis of malignant mesothelioma. In this overview, current published studies concerning pathogenesis of malignant mesothelioma are reviewed, with insights into its etiology and pathogenesis. We searched pubmed using the following subjects: mesothelioma, radiation, genetics, pediatric malignant mesothelioma, SV40 virus, and growth factors. We selected 350 valuable articles of which 152 sources were used to complete this review.

Conclusion

Many risk factors for MPM development have been recognized including environmental exposures, genetic susceptibility, viral contamination, and radiation. In this review, we discuss the current molecular and genetic contributors to MPM pathogenesis and the risk factors associated with these carcinogenic processes.

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Title: Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors
Authors: Shoshana J. Weiner
Siyamek Neragi-Miandoab
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 1/2009
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-008-0444-9

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Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors

Abstract

Background

Methods

Conclusion

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Abstract

Background

Methods

Conclusion

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