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Journal of Cancer Research and Clinical Oncology

01-11-2007 | Original Paper

Combination therapy of S-1 and CDDP for patients with colorectal cancer

Authors: Kazumi Uchida, Kazuhiko Hayashi, Hidekazu Kuramochi, Go Nakajima, Yuji Inoue, Masakazu Yamamoto

Published in: Journal of Cancer Research and Clinical Oncology | Issue 11/2007

Abstract

Purpose

We evaluate the feasibility and efficacy of S-1 in combination with cisplatin (CDDP) for patients with colorectal cancer.

Methods

A total of 52 patients with advanced or recurrent colorectal cancer were included. S-1 was given orally twice daily for 21 days and CDDP 30 mg/m² on day 1 and 8, followed by a 2-week period of no treatment.

Results

Tumor responses among patients included 18 PR, 12 SD, and 16 PD (n = 46). The overall response rate was 36.4% (18/46). The response rate of the patients with prior chemotherapy was 22.2% (4/18) and 50.0% (12/24) among the patients who had no prior therapy. The median survival periods were 555 days and the median progression free survival periods were 183 days, respectively. S-1 in combination with CDDP shows promising activity with acceptable toxicities against colorectal cancer.

Conclusions

A combination of S-1 and CDDP could be a standard therapy for treating colorectal carcinoma.

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Title: Combination therapy of S-1 and CDDP for patients with colorectal cancer
Authors: Kazumi Uchida
Kazuhiko Hayashi
Hidekazu Kuramochi
Go Nakajima
Yuji Inoue
Masakazu Yamamoto
Publication date: 01-11-2007
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 11/2007
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-007-0226-9

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New intervention for STEMI-related cardiogenic shock

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