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01-08-2019 | Review

Impact of CMV upon immune aging: facts and fiction

Authors: Mladen Jergović, Nico A. Contreras, Janko Nikolich-Žugich

Published in: Medical Microbiology and Immunology | Issue 3-4/2019

Abstract

Aging is accompanied by significant defects in immunity and compromised responses to new, previously unencountered microbial pathogens. Most humans carry several persistent or latent viruses as they age, interacting with the host immune systems for years. In that context maybe the most studied persistent virus is Cytomegalovirus, infamous for its ability to recruit very large T cell responses which increase with age and to simultaneously evade elimination by the immune system. Here we will address how lifelong CMV infection and the immunological burden of its control might affect immune reactivity and health of the host over time.

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Title: Impact of CMV upon immune aging: facts and fiction
Authors: Mladen Jergović
Nico A. Contreras
Janko Nikolich-Žugich
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Published in: Medical Microbiology and Immunology / Issue 3-4/2019
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-019-00605-w

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