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01-08-2019 | Septicemia | Review

Impact of cytomegalovirus load on host response to sepsis

Authors: Thomas Marandu, Michael Dombek, Charles H. Cook

Published in: Medical Microbiology and Immunology | Issue 3-4/2019

Abstract

There is a decades old association between cytomegalovirus reactivation and sepsis in immune-competent hosts. Much has been learned about this relationship, which has been described as bidirectional, meaning that the virus incites and is incited by the host’s inflammatory response. More recent work has suggested that chronic viral infection leaves the host with exaggerated immunity to bacterial infections. In this review, the relationship between CMV and host responses to sepsis are reviewed, with particular attention to the impact that tissue viral load contributes to this phenomenon.

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Title: Impact of cytomegalovirus load on host response to sepsis
Authors: Thomas Marandu
Michael Dombek
Charles H. Cook
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Keywords: Septicemia
Septicemia
Epigenetics
Published in: Medical Microbiology and Immunology / Issue 3-4/2019
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-019-00603-y

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Impact of cytomegalovirus load on host response to sepsis

Abstract

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Abstract

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