Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Medical Microbiology and Immunology
Published in: Medical Microbiology and Immunology 5-6/2018

01-11-2018 | Review

Preventing vertical virus infections: the role of serologic screening of pregnant women

Authors: Annemarie Berger, Hans Wilhelm Doerr

Published in: Medical Microbiology and Immunology | Issue 5-6/2018

Login to get access

Abstract

Several virus infections affect the pregnancy itself as well as the foetal development (rubella, PVB19, VZV, HSV, HCMV, HBV, HIV). Prevention can be established by vaccination or an assessment of the immunity status as well as by chemotherapy. The following review provides an update to current aspects focusing on the role of serologic screening.
Literature
1.
2.
Vauloup-Fellous C (2018) Standardization of rubella immunoassays. J Clin Virol 102:34–38CrossRef
3.
4.
5.
Bonvicini F. Bua G, Gallinella G (2017) Parvovirus B19 infection in pregnancy-awareness and opportunities. Curr Opin Virol 27:8–14CrossRef
6.
Public Health Laboratory Service Working Party on Fifth Disease (1990) Prospective study of human parvovirus (B19) infection in pregnancy. BMJ 300:1166–1170CrossRef
7.
Rodis JF, Quinn DL, Gary GW Jr, Anderson LJ (1990) Management and outcomes of pregnancies complicated by human B19 parvovirus infection: a prospective study. Am J Obstet Gynecol 163:1168–1171CrossRef
8.
Reinheimer C, Allwinn R, Doerr HW, Wittek M (2010) Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors. Infection 38:381–385CrossRef
9.
Barlinn R, Rollag H, Trogstad L et al (2017) High incidence of maternal parvovirus B19 infection in a large unselected population-based pregnancy cohort in Norway. J Clin Virol 94:57–62CrossRef
10.
Bredl S, Plentz A, Wenzel JJ, Pfister H, Möst J, Modrow S (2011) False-negative serology in patients with acute parvovirus B19 infection. J Clin Virol 51:115–120CrossRef
11.
Crane J, Mundle W, Boucoiran I et al (2014) Parvovirus B19 in pregnancy. J Obstet Gynaecol Can 36:1107–1116CrossRef
12.
Matsuda H, Sakaguchi K, Shibasaki T, Takahashi H, Kawakami Y, Furuya K (2005) Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin. J Perinat Med 33:561–563
13.
Pasternak B, Hviid A (2010) Use of acyclovir, valacyclovir and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 304:859–866CrossRef
14.
Sauerbrei A, Wutzler P (2007) Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: varicella-zoster virus infections. Med Microbiol Immunol 196:95–102CrossRef
15.
Wiese-Posselt M, Siedler A, Mankertz A et al (2017) Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany. BMC Infect Dis 17:356CrossRef
16.
Werner RN, Nikkels AF, Marinović B et al (2017) European consensus-based (S2k) guideline on the management of herpes zoster—guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), part 1: diagnosis. J Eur Acad Dermatol Venereol 31:9–19CrossRef
17.
Doerr HW (2013) Progress in VZV vaccination? Some concerns. Med Microbiol Immunol 202:257–258CrossRef
18.
Wicker S, Rabenau HF, Gottschalk R, Doerr HW, Allwinn R (2007) Seroprevalence of vaccine preventable and blood transmissible viral infections (measles, mumps, rubella, VZV, polio, HBV, HCV and HIV) in medical students. Med Microbiol Immunol 196:145–150CrossRef
19.
Wittek M, Doerr HW, Allwinn R (2010) Varicella and herpes zoster. Part 1: virology, epidemiology, clinical picture, laboratory diagnostics. Med Klin (Munich) 105:334–338CrossRef
20.
Buxbaum S, Geers M, Gross G, Schöfer H, Rabenau HF, Doerr HW (2003) Epidemiology of herpes simplex virus types 1 and 2 in Germany: what has changed? Med Microbiol Immunol 192:177–181CrossRef
21.
22.
Kimberlin D (2004) Neonatal herpes simplex infection. Clin Microbiol Rev 17(1):1–13CrossRef
23.
Hollier LM, Wendel GD (2008) Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection. Cochrane Database Syst Rev 1:CD004946
24.
Pichler M, Staffler A, Bonometti N, Messner H, Deluca J, Thuile T, Kluge R, Schmuth M, Eisendle K (2015) Premature newborns with fatal intrauterine herpes simplex virus-1 infection: first report of twins and review of the literature. J Eur Acad Dermatol Venereol 29:1216–1220CrossRef
25.
Doerr HW, Berger A (2014) Vaccination against infectious diseases. What is promising? Med Microbiol Immunol 203:365–371CrossRef
26.
Lübeck PR, Doerr HW, Rabenau HF (2010) Epidemiology of human cytomegalovirus (HCMV) in an urban region of Germany: what has changed? Med Microbiol Immunol 199:53–60CrossRef
27.
Enders G, Daiminger A, Lindemann L, Knotek F, Bäder U, Exler S, Enders M (2012) Cytomegalovirus (CMV) seroprevalence in pregnant women, bone marrow donors and adolescents in Germany, 1996–2010. Med Microbiol Immunol 201:303–309CrossRef
28.
Rycel M, Wujcicka W, Zawilińska B, Paradowska E, Suski P, Gaj Z, Wilczyński J, Leśnikowski Z, Nowakowska D (2015) Mixed infections with distinct cytomegalovirus glycoprotein B genotypes in Polish pregnant women, foetuses, and newborns. Eur J Clin Microbiol Infect Dis 34:585–591CrossRef
29.
Kagan KO, Hamprecht K (2017) Cytomegalovirus in pregnancy. Arch Gynecol Obstet 296:15–26CrossRef
30.
Doerr HW (1987) Cytomegalovirus infection in pregnancy. J Virol Methods 17:127–132CrossRef
31.
Britt W (2015) Controversies in the natural history of congenital human cytomegalovirus infection: the paradox of infection and disease in offspring of women with immunity prior to pregnancy. Med Microbiol Immunol 204:263–271CrossRef
32.
Berger A, Reitter A, Harter PN, Buxmann H, Allwinn R, Louwen F, Doerr HW (2011) Problems and challenges in the diagnosis of vertical infection with human cytomegalovirus (CMV): lessons from two accidental cases. J Clin Virol 51:285–288CrossRef
33.
Doerr HW (2016) Fighting cytomegalovirus-caused diseases: the immunologic approach. Med Microbiol Immunol 205:511–512CrossRef
34.
Lanzieri TM, Dollard SC, Josephson CD, Schmid DS, Bialek SR (2013) Breast milk-acquired cytomegalovirus infection and disease in very low birth weight and premature infants. Pediatrics 131(6):e1937–e1945CrossRef
35.
Reitter A, Buxmann H, Haberl AE, Schlösser R, Kreibich M, Keppler OT, Berger A (2016) Incidence of CMV co-infection in HIV-positive women and their neonates in a tertiary referral centre: a cohort study. Med Microbiol Immunol 205:63–71CrossRef
36.
Wagner N, Kagan KO, Haen S, Schmidt S et al (2014) Effective management and intrauterine treatment of congenital cytomegalovirus infection: review article and case series. J Matern Fetal Neonatal Med 27:209–214CrossRef
37.
Seidel V, Feiterna-Sperling C, Siedentopf JP, Hofmann J et al (2017) Intrauterine therapy of cytomegalovirus infection with valganciclovir: review of the literature. Med Microbiol Immunol 206:347–354CrossRef
38.
Rawlinson W (2017) Congenital CMV international guidelines are needed to guide diagnosis, prevention and management. Acta Paediatr 106(9):1389–1390CrossRef
39.
Hamprecht K, Kagan KO, Schampera M, Jahn G (2018) Impact of pharmacokinetics on the efficiency of CMV-specific hyperimmune globulin treatment in early CMV-primary infection during pregnancy (abstract). In: 28th annual meeting of the Society for Virology, March 14–17, Würzburg, OP 137
40.
Plotkin S (2015) The history of vaccination against cytomegalovirus. Med Microbiol Immunol 204:247–254CrossRef
41.
Mocarski ES (2015) Stanley Plotkin: the bright spark of cytomegalovirus vaccines. Med Microbiol Immunol 204:243–245CrossRef
42.
Plachter B (2016) Prospects a vaccine for the prevention of congenital cytomegalovirus disease. Med Microbiol Immunol 205:537–547CrossRef
43.
Mavilia MG, Wu GY (2017) Mechanisms and prevention of vertical transmission in chronic viral hepatitis. J Clin Transl Hepatol 5:119–129 (Review) CrossRef
44.
Nakagawa F, Phillips AN, Lundgren JD (2014) Update on HIV in Western Europe. Curr HIV/AIDS Rep 11:177–185 (Review) CrossRef
45.
Vrazo AC, Firth J, Amzel A, Sedillo R, Ryan J, Phelps BR (2018) Interventions to significantly improve service uptake and retention of HIV-positive pregnant women and HIV-exposed infants along the PMTCT continuum of care. A systematic review. Trop Med Int Health 23:136–148CrossRef
46.
Park JS, Pan CQ (2017) Viral factors for HBV mother-to-child transmission. Hepatol Int 11:476–480CrossRef
47.
Weis N, Cowan S, Hallager S, Dröse S et al (2017) Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark. Scand J Gastroenterol 52:178–184CrossRef
48.
Tavakolpour S, Darvishi M, Mirsafaei HS, Ghasemiadl M (2018) Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B infection during pregnancy: a systematic review. Infect Dis (Lond) 50:95–106
49.
Gerlich WH (2015) Prophylactic vaccination against hepatitis B: achievements, challenges and perspectives. Med Microbiol Immunol 204:39–55CrossRef
50.
Shouval D. Roggendorf H, Roggendorf M (2015) Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1/Pre-S2/S vaccine. Med Microbiol Immunol 204:57–68CrossRef
51.
Doerr HW (2013) Perspectives of vaccination in adults. Expert Rev Vaccines 12:593–596CrossRef
52.
53.
Metadata
Title
Preventing vertical virus infections: the role of serologic screening of pregnant women
Authors
Annemarie Berger
Hans Wilhelm Doerr
Publication date
01-11-2018
Publisher
Springer Berlin Heidelberg
Published in
Medical Microbiology and Immunology / Issue 5-6/2018
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-018-0549-y

Other articles of this Issue 5-6/2018

Medical Microbiology and Immunology 5-6/2018 Go to the issue

Original Investigation

The interplay between local immune response and Epstein–Barr virus-infected tonsillar cells could lead to viral infection control

Rapid Communication

Lopinavir serum concentrations of critically ill infants: a pharmacokinetic investigation in South Africa

Review

PA-X: a key regulator of influenza A virus pathogenicity and host immune responses

Original Investigation

Vaccine adjuvants CpG (oligodeoxynucleotides ODNs), MPL (3-O-deacylated monophosphoryl lipid A) and naloxone-enhanced Th1 immune response to the Plasmodium vivax recombinant thrombospondin-related adhesive protein (TRAP) in mice

Original Investigation

Contribution of toxic shock syndrome toxin-1 to systemic inflammation investigated by a mouse model of cervicovaginal infection with Staphylococcus aureus

Original Investigation

Phosphorylcholine is located in Aggregatibacter actinomycetemcomitans fimbrial protein Flp 1

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24 to hear Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits