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01-01-2017 | Brief Report

Infrequent mismatch repair protein loss in gallbladder cancer patients in Japan

Authors: Hiroshi Yoshida, Kazuaki Shimada, Nobuyoshi Hiraoka

Published in: Virchows Archiv | Issue 1/2017

Excerpt

Gallbladder cancer (GBC) represents a rare malignancy worldwide. Its prognosis is poor, and in Chile and East Asia, including Japan and China, a relative increase in the incidence of GBC has been observed [1]. The development of new therapies is required for the treatment of this aggressive and intractable type of cancer. Recently, novel immunotherapy approaches against cancers with microsatellite instability (MSI) have been developed, and MSI is reported to be a predictive biomarker of response to treatment with pembrolizumab, an antibody against programmed cell death protein (PD-1) [2, 3]. In biliary tract cancers with MSI, this therapy might hold promise, which had increased the need for identification of MSI cancers. …

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Title: Infrequent mismatch repair protein loss in gallbladder cancer patients in Japan
Authors: Hiroshi Yoshida
Kazuaki Shimada
Nobuyoshi Hiraoka
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 1/2017
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-016-2043-5

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