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Published in: Virchows Archiv 5/2011

01-11-2011 | Original Article

A critical analysis of three quantitative methods of assessment of hepatic steatosis in liver biopsies

Authors: Mariana Catta-Preta, Leonardo Souza Mendonca, Julio Fraulob-Aquino, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda

Published in: Virchows Archiv | Issue 5/2011

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Abstract

The issue of adequately quantitatively evaluating hepatic steatosis is still unresolved. Therefore, we compared three methods of quantitative assessment. Two groups of mice (n = 10 each) were fed standard chow (10% fat, SC group) or a high-fat diet (60% fat, HF group) for 16 weeks, and hepatic triglyceride (HT) and liver tissue were then studied. Paraplast-embedded tissues stained by hematoxylin and eosin (H-E) were compared to frozen sections stained by Oil Red-O (ORO). In addition, the volume density of steatosis (Vv[steatosis, liver]) was measured by point counting (P-C, sections H-E or ORO) or by image analysis (I-A, sections ORO). HT was significantly higher in the HF group (104% greater, P = 0.0004) than in the SC group. With P-C and H-E, Vv[steatosis, liver] was 4.80 ± 0.90% in the SC group and 33.50 ± 3.17% in the HF group (600% greater, P < 0.0001). With P-C and ORO, Vv[steatosis, liver] was 4.86 ± 0.89% in the SC group and 25.21 ± 1.27% in the HF group (420% greater, P < 0.0001). With I-A and ORO, Vv[steatosis, liver] was 4.17 ± 0.85% in the SC group and 23.35 ± 1.58% in the HF group (460% greater, P < 0.0001). Correlations between Vv[steatosis, liver] and HT were strong and significant in all methods. In conclusion, all methods were appropriate and reproducible. In P-C and H-E, there is a slight overestimation of steatosis in the HF animals in comparison to frozen sections and ORO; in frozen sections, differences between P-C and I-A are insignificant.
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Metadata
Title
A critical analysis of three quantitative methods of assessment of hepatic steatosis in liver biopsies
Authors
Mariana Catta-Preta
Leonardo Souza Mendonca
Julio Fraulob-Aquino
Marcia Barbosa Aguila
Carlos Alberto Mandarim-de-Lacerda
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 5/2011
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-011-1147-1

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