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01-11-2011 | Original Article

Aggressive B cell lymphomas of the gastrointestinal tract: clinicopathologic and genetic analysis

Authors: Song-Yi Choi, Seok Jin Kim, Won Seog Kim, Kihyun Kim, Young-Hyeh Ko

Published in: Virchows Archiv | Issue 5/2011

Abstract

Aggressive B cell lymphomas of the gastrointestinal tract include Burkitt lymphoma (BL), diffuse large B cell lymphoma, and B cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL. To investigate the clinical characters of DLBCL/BL of the gastrointestinal (GI) tract, 101 cases of aggressive B cell lymphoma of the GI tract were analyzed by immunohistochemistry and fluorescence in situ hybridization (FISH) using break apart probe for c-MYC gene. For cases with c-MYC rearrangement, additional FISH studies with MYC/IgH fusion probe, BCL2 break apart probe, and BCL6 break apart probe were performed. MYC rearrangement was detected in 23 of 101 cases of aggressive B cell lymphomas (22.5%). The cases with MYC rearrangement were divided into 14 BL, three DLBCL/BL, and six DLBCL. One of the three DLBCL/BL had double translocation for MYC and BCL6 gene. Clinically, DLBCL/BL of the GI tract was more akin to Burkitt lymphoma than it is to GI tract DLBCL with c-MYC rearrangement. The overall prognosis of patients with DLBCL/BL was the worst among aggressive B cell lymphomas. DLBCL/BL is uncommon category of B cell lymphoma in the GI tract with aggressive clinical course despite of intensive chemotherapy.

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Title: Aggressive B cell lymphomas of the gastrointestinal tract: clinicopathologic and genetic analysis
Authors: Song-Yi Choi
Seok Jin Kim
Won Seog Kim
Kihyun Kim
Young-Hyeh Ko
Publication date: 01-11-2011
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 5/2011
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-011-1153-3

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Aggressive B cell lymphomas of the gastrointestinal tract: clinicopathologic and genetic analysis

Abstract

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