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Virchows Archiv
Published in: Virchows Archiv 2/2010

01-02-2010 | Review and Perspective

Well-differentiated and dedifferentiated liposarcomas

Authors: Jean-Michel Coindre, Florence Pédeutour, Alain Aurias

Published in: Virchows Archiv | Issue 2/2010

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Abstract

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14–15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.
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Metadata
Title
Well-differentiated and dedifferentiated liposarcomas
Authors
Jean-Michel Coindre
Florence Pédeutour
Alain Aurias
Publication date
01-02-2010
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 2/2010
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-009-0815-x

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