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01-02-2010 | Review and Perspective

Soft tissue sarcomas with complex genomic profiles

Authors: Louis Guillou, Alain Aurias

Published in: Virchows Archiv | Issue 2/2010

Abstract

Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurrent aberrations (e.g., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. Features of diagnostic or prognostic relevance will be discussed when needed.

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Title: Soft tissue sarcomas with complex genomic profiles
Authors: Louis Guillou
Alain Aurias
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 2/2010
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0853-4

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Soft tissue sarcomas with complex genomic profiles

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