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Langenbeck's Archives of Surgery
Published in: Langenbeck's Archives of Surgery 3/2017

01-05-2017 | ORIGINAL ARTICLE

Influence of prognostic nutritional index and tumor markers on survival in gastric cancer surgery patients

Authors: Hiroaki Saito, Yusuke Kono, Yuki Murakami, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki

Published in: Langenbeck's Archives of Surgery | Issue 3/2017

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Abstract

Purpose

Blood analytes are easily used in routine clinical practice. Tumor markers (TMs) are useful in diagnosing, treating, and predicting prognosis of gastric cancer (GC). The prognostic nutritional index (PNI) was also recently found to be useful in predicting GC prognosis.

Methods

The PNI and serum levels of CEA and CA19-9 of 453 patients with GC were measured to examine correlations between those levels and patients’ prognoses.

Results

Of the 453 patients, 84 (18.5%) were positive for CEA and/or CA19-9 and therefore considered positive for TMs. Prognosis of patients who were TM+ was significantly worse than for those who were TM−. Mean PNI was 48.2 (range 27.7–63.6). ROC analysis indicated that 46.7 was the optimal PNI cutoff value. Prognosis of patients in the PNILow group (<46.7) was significantly worse than in the PNIHigh group (≥46.7). Prognosis of patients who were both TM+ and PNILow was significantly worse than that of patients who were either TM+ or PNILow and those who were both TM− and PNIHigh. Multivariate analysis indicated that combination of TM and PNI was an independent prognostic indicator.

Conclusions

The combination of TM and PNI offers accurate information about a patient’s prognosis.
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Metadata
Title
Influence of prognostic nutritional index and tumor markers on survival in gastric cancer surgery patients
Authors
Hiroaki Saito
Yusuke Kono
Yuki Murakami
Hirohiko Kuroda
Tomoyuki Matsunaga
Yoji Fukumoto
Tomohiro Osaki
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 3/2017
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-017-1572-y

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