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01-05-2017 | ORIGINAL ARTICLE

Effects of a preoperative immune-modulating diet in patients with esophageal cancer: a prospective parallel group randomized study

Authors: Hiroyuki Kitagawa, Tsutomu Namikawa, Tomoaki Yatabe, Masaya Munekage, Fumiyasu Yamasaki, Michiya Kobayashi, Kazuhiro Hanazaki

Published in: Langenbeck's Archives of Surgery | Issue 3/2017

Abstract

Purpose

The aim of this pilot study was to investigate the effects of a preoperative immune-modulating diet (IMD) before thoracoscopic esophagectomy for patients with esophageal cancer.

Methods

Thirty patients who were diagnosed with resectable esophageal cancer were assigned to two groups: the IMD (n = 15) and the standard liquid diet (SLD; n = 15) groups. We evaluated postoperative parameters, such as the incidence of complications and the postoperative levels of cytokines as the primary endpoints. The secondary endpoint was the length of hospital stay.

Results

The peak levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α appeared on postoperative day (POD) 1 and POD 2 in the IMD and SLD group, respectively. The peak level of C-reactive protein (CRP) appeared on POD 3 in both groups (IMD 9.9 mg/dL, SLD 15.2 mg/dL).

Overall, TNF-α levels in the IMD group were lower than those in the SLD group (P = 0.033). Furthermore, IL-6 (P = 0.182) and CRP (P = 0.191) levels, and the incidence of postoperative pneumonia (7.1 vs. 26.7%; P = 0.330) tended to be lower in the IMD group than in the SLD group.

Conclusions

Preoperative IMD suppressed the elevation of the TNF-α levels after thoracoscopic esophagectomy in patients with esophageal cancer, although no different tendency was detected in terms of IL-6, CRP or postoperative complications.

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Title: Effects of a preoperative immune-modulating diet in patients with esophageal cancer: a prospective parallel group randomized study
Authors: Hiroyuki Kitagawa
Tsutomu Namikawa
Tomoaki Yatabe
Masaya Munekage
Fumiyasu Yamasaki
Michiya Kobayashi
Kazuhiro Hanazaki
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 3/2017
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-016-1538-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of a preoperative immune-modulating diet in patients with esophageal cancer: a prospective parallel group randomized study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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