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01-01-2011 | Original Article

Diagnostic value of thyroglobulin measurement in fine-needle aspiration biopsy for detecting metastatic lymph nodes in patients with papillary thyroid carcinoma

Authors: Artür Salmaslıoğlu, Yeşim Erbil, Gamze Çıtlak, Feyzullah Ersöz, Serkan Sarı, Aydemir Olmez, Mehtap Tunacı, Dilek Yılmazbayhan, Neşe Çolak, Selçuk Özarmağan

Published in: Langenbeck's Archives of Surgery | Issue 1/2011

Abstract

Purpose

We aimed to compare the diagnostic value of fine-needle aspiration cytology (FNAC) and fine-needle aspiration thyroglobulin measurements (FNA-Tg) for detecting cervical lymph node metastases from differentiated thyroid carcinomas.

Methods

This prospective study included 225 patients with neck node metastases or recurrences of papillary thyroid carcinoma. From the 225 patients, 255 lymph nodes were evaluated by FNAC and FNA-Tg. Final diagnoses confirmed by histological examination were compared to preoperative FNAC and FNA-Tg results.

Results

FNAC correctly diagnosed 212 metastatic lymph nodes but failed to diagnose 43 of them. FNA-Tg correctly diagnosed 253 metastatic lymph nodes but failed to diagnose two of them. FNA-Tg levels showed 100% sensitivity, 96% specificity, 99% diagnostic accuracy, a 99% positive predictive value (PPV) and a 100% negative predictive value (NPV) with a threshold level of FNA-Tg with a diagnostic accuracy 28.5 ng/ml. The specificity, diagnostic accuracy, PPV and NPV of FNA-Tg were significantly higher than those of FNAC.

Conclusion

FNA-Tg measurement can be performed safely for the detection of lymph node metastasis in patients with differentiated thyroid carcinomas.

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Title: Diagnostic value of thyroglobulin measurement in fine-needle aspiration biopsy for detecting metastatic lymph nodes in patients with papillary thyroid carcinoma
Authors: Artür Salmaslıoğlu
Yeşim Erbil
Gamze Çıtlak
Feyzullah Ersöz
Serkan Sarı
Aydemir Olmez
Mehtap Tunacı
Dilek Yılmazbayhan
Neşe Çolak
Selçuk Özarmağan
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 1/2011
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-010-0723-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Diagnostic value of thyroglobulin measurement in fine-needle aspiration biopsy for detecting metastatic lymph nodes in patients with papillary thyroid carcinoma

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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