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European Journal of Applied Physiology

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01-03-2022 | Hypertension | Original Article

Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients

Authors: Jamie M. O’Driscoll, Jamie J. Edwards, Jonathan D. Wiles, Katrina A. Taylor, Paul Leeson, Rajan Sharma

Published in: European Journal of Applied Physiology | Issue 3/2022

Abstract

Purpose

Hypertension is a major risk factor for cardiovascular disease. Isometric exercise training (IET) reduces resting and ambulatory blood pressure; however, few studies have investigated the myocardial adaptations following IET.

Methods

We randomly assigned 24 unmedicated hypertensive patients in a cross-over study design to 4-weeks of IET and control period, separated by a 3-week washout period. Speckle tracking echocardiography was used to measure left ventricular (LV) mechanics, and global myocardial work indices were derived from non-invasive LV pressure-strain loops constructed from global longitudinal strain (GLS) indexed to brachial systolic blood pressure.

Results

IET significantly improved GLS (− 2.3 ± 2%, p < 0.001) and global work efficiency (2.8 ± 2%, p < 0.001), and significantly reduced global wasted work (− 42.5 ± 30 mmHg%, p < 0.001) with no significant change during the control period.

Conclusions

This is the first evidence to demonstrate that IET significantly improved cardiac health in a relevant patient population. Our findings have important clinical implications for patients with high blood pressure and support the role of IET as a safe and viable therapeutic and preventative intervention in the treatment of hypertension.

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Title: Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients
Authors: Jamie M. O’Driscoll
Jamie J. Edwards
Jonathan D. Wiles
Katrina A. Taylor
Paul Leeson
Rajan Sharma
Publication date: 01-03-2022
Publisher: Springer Berlin Heidelberg
Keywords: Hypertension
Hypertension
Published in: European Journal of Applied Physiology / Issue 3/2022
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-021-04882-3

At a glance: The STEP trials

Springer Medicine

Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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