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01-12-2017 | Original Article

Acute and chronic changes in baroreflex sensitivity in hypobaric vs. normobaric hypoxia

Authors: Nicolas Bourdillon, Jonas Saugy, Laurent Schmitt, Thomas Rupp, Sasan Yazdani, Jean-Marc Vesin, Grégoire P. Millet

Published in: European Journal of Applied Physiology | Issue 12/2017

Abstract

Normobaric hypoxia (NH) is used as a surrogate for hypobaric hypoxia (HH). Recent studies reported physiological differences between NH and HH. Baroreflex sensitivity (BRS) decreases at altitude or following intense training. However, until now no study compared the acute and chronic changes of BRS in NH vs. HH. First, BRS was assessed in 13 healthy male subjects prior and after 20 h of exposure at 3450 m (study 1), and second in 15 well-trained athletes prior and after 18 days of “live-high train-low” (LHTL) at 2250 m (study 2) in NH vs. HH. BRS decreased (p < 0.05) to the same extent in NH and HH after 20 h of hypoxia and after LHTL. These results confirm that altitude decreases BRS but the decrease is similar between HH and NH. The persistence of this decrease after the cessation of a chronic exposure is new and does not differ between HH and NH. The previously reported physiological differences between NH and HH do not appear strong enough to induce different BRS responses.

Baumert M, Brechtel L, Lock J et al (2006) Heart rate variability, blood pressure variability, and baroreflex sensitivity in overtrained athletes. Clin J Sport Med Off J Can Acad Sport Med 16:412–417. doi:10.1097/01.jsm.0000244610.34594.07 CrossRef

Chapleau MW (2003) Determinants of baroreflex sensitivity in health and disease: from correlates to causality. Clin Auton Res Off J Clin Auton Res Soc 13:310–313. doi:10.1007/s10286-003-0131-5 CrossRef

Conkin J, Wessel JH (2008) Critique of the equivalent air altitude model. Aviat Space Environ Med 79:975–982CrossRef

Cooper VL, Pearson SB, Bowker CM et al (2005) Interaction of chemoreceptor and baroreceptor reflexes by hypoxia and hypercapnia—a mechanism for promoting hypertension in obstructive sleep apnoea. J Physiol 568:677–687. doi:10.1113/jphysiol.2005.094151 CrossRefPubMedPubMedCentral

Coppel J, Hennis P, Gilbert-Kawai E, Grocott MP (2015) The physiological effects of hypobaric hypoxia versus normobaric hypoxia: a systematic review of crossover trials. Extreme Physiol Med 4:2. doi:10.1186/s13728-014-0021-6 CrossRef

Cowley AW, Liard JF, Guyton AC (1973) Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res 32:564–576CrossRef

DiPasquale DM, Strangman GE, Harris NS, Muza SR (2016) Acute mountain sickness symptoms depend on normobaric versus hypobaric hypoxia. BioMed Res Int. doi:10.1155/2016/6245609 CrossRefPubMedPubMedCentral

Faiss R, Pialoux V, Sartori C et al (2013) Ventilation, oxidative stress, and nitric oxide in hypobaric versus normobaric hypoxia. Med Sci Sports Exerc 45:253–260. doi:10.1249/MSS.0b013e31826d5aa2 CrossRefPubMed

Girard O, Koehle MS, MacInnis MJ et al (2012) Comments on point: counterpoint: hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia. J Appl Physiol Bethesda Md 112:1788–1794. doi:10.1152/japplphysiol.00356.2012 CrossRef

Gratze G, Rudnicki R, Urban W et al (2005) Hemodynamic and autonomic changes induced by Ironman: prediction of competition time by blood pressure variability. J Appl Physiol Bethesda Md 99:1728–1735. doi:10.1152/japplphysiol.00487.2005 CrossRef

Hauser A, Troesch S, Saugy JJ et al (2017) Individual hemoglobin mass response to normobaric and hypobaric “live high-train low”: a 1-year crossover study. J Appl Physiol Bethesda Md. doi:10.1152/japplphysiol.00932.2016 CrossRef

Heinzer R, Saugy JJ, Rupp T et al (2016) Comparison of sleep disorders between real and simulated 3450-m altitude. Sleep 39:1517–1523. doi:10.5665/sleep.6010 CrossRefPubMedPubMedCentral

Huang C-C, Lin W-C, Chen H-L et al (2016) Improvement of baroreflex sensitivity in patients with obstructive sleep apnea following surgical treatment. Clin Neurophysiol Off J Int Fed Clin Neurophysiol 127:544–550. doi:10.1016/j.clinph.2015.05.022 CrossRef

Hughson RL, Maillet A, Gharib C et al (1994a) Reduced spontaneous baroreflex response slope during lower body negative pressure after 28 days of head-down bed rest. J Appl Physiol Bethesda Md 77:69–77

Hughson RL, Yamamoto Y, McCullough RE et al (1994b) Sympathetic and parasympathetic indicators of heart rate control at altitude studied by spectral analysis. J Appl Physiol Bethesda Md 77:2537–2542

Iellamo F, Legramante JM, Pigozzi F et al (2002) Conversion from vagal to sympathetic predominance with strenuous training in high-performance world class athletes. Circulation 105:2719–2724CrossRef

La Rovere MT, Bigger JT, Marcus FI et al (1998) Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (autonomic tone and reflexes after myocardial infarction) investigators. Lancet Lond Engl 351:478–484CrossRef

Millet GP, Debevec T, Brocherie F et al (2016) Therapeutic use of exercising in hypoxia: promises and limitations. Front Physiol 7:224. doi:10.3389/fphys.2016.00224 CrossRefPubMedPubMedCentral

Mirmohamadsadeghi L, Bourdillon N, Vesin J (2016) Cardio-respiratory characterization of the autonomic balance. In: Computing in cardiology. IEEE, Vancouver

Parati G, Di Rienzo M, Bertinieri G et al (1988) Evaluation of the baroreceptor-heart rate reflex by 24-h intra-arterial blood pressure monitoring in humans. Hypertens Dallas Tex 12:214–222CrossRef

Parati G, Di Rienzo M, Mancia G (2001) Dynamic modulation of baroreflex sensitivity in health and disease. Ann N Y Acad Sci 940:469–487CrossRef

Pinna GD, Maestri R, La Rovere MT (2015) Assessment of baroreflex sensitivity from spontaneous oscillations of blood pressure and heart rate: proven clinical value? Physiol Meas 36:741–753. doi:10.1088/0967-3334/36/4/741 CrossRefPubMed

Ponchia A, Noventa D, Bertaglia M et al (1994) Cardiovascular neural regulation during and after prolonged high altitude exposure. Eur Heart J 15:1463–1469CrossRef

Querido JS, Wehrwein EA, Hart EC et al (2011) Baroreflex control of muscle sympathetic nerve activity as a mechanism for persistent sympathoexcitation following acute hypoxia in humans. Am J Physiol Regul Integr Comp Physiol 301:R1779-1785. doi:10.1152/ajpregu.00182.2011 CrossRef

Ribon A, Pialoux V, Saugy JJ et al (2016) Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia. Respir Physiol Neurobiol 223:23–27. doi:10.1016/j.resp.2015.12.008 CrossRefPubMed

Roche F, Reynaud C, Garet M et al (2002) Cardiac baroreflex control in humans during and immediately after brief exposure to simulated high altitude. Clin Physiol Funct Imaging 22:301–306CrossRef

Saugy JJ, Schmitt L, Cejuela R et al (2014) Comparison of “live high-train low” in normobaric versus hypobaric hypoxia. PloS One 9:e114418. doi:10.1371/journal.pone.0114418 CrossRefPubMedPubMedCentral

Saugy JJ, Rupp T, Faiss R et al (2016a) Cycling time trial is more altered in hypobaric than normobaric hypoxia. Med Sci Sports Exerc 48:680–688. doi:10.1249/MSS.0000000000000810 CrossRefPubMed

Saugy JJ, Schmitt L, Hauser A et al (2016b) Same performance changes after live high-train low in normobaric vs. hypobaric hypoxia Front Physiol 7:138. doi:10.3389/fphys.2016.00138 CrossRefPubMedPubMedCentral

Somers VK, Mark AL, Abboud FM (1991) Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 87:1953–1957. doi:10.1172/JCI115221 CrossRefPubMedPubMedCentral

Subudhi AW, Fan J-L, Evero O et al (2014) AltitudeOmics: cerebral autoregulation during ascent, acclimatization, and re-exposure to high altitude and its relation with acute mountain sickness. J Appl Physiol 116:724–729. doi:10.1152/japplphysiol.00880.2013 CrossRefPubMed

Tremblay JC, Boulet LM, Tymko MM, Foster GE (2016) Intermittent hypoxia and arterial blood pressure control in humans: role of the peripheral vasculature and carotid baroreflex. Am J Physiol Heart Circ Physiol 311:H699–706. doi:10.1152/ajpheart.00388.2016 CrossRefPubMed

Van De Borne P, Mezzetti S, Montano N et al (2000) Hyperventilation alters arterial baroreflex control of heart rate and muscle sympathetic nerve activity. Am J Physiol Heart Circ Physiol 279:H536–541CrossRef

Vasquez EC, Meyrelles SS, Mauad H, Cabral AM (1997) Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex. Braz J Med Biol Res Rev Bras Pesqui Med E Biol 30:521–532CrossRef

Yamamoto Y, Hoshikawa Y, Miyashita M (1996) Effects of acute exposure to simulated altitude on heart rate variability during exercise. J Appl Physiol Bethesda Md 81:1223–1229

Yazdani S, Bourdillon N, Lovering A et al (2016a) AltitudeOmics: effect of exercise on baroreflex sensitivity at sea level and altitude. In: Computing in cardiology. IEEE, Vancouver, BC, pp 529–532

Yazdani S, Bourdillon N, Subudhi AW et al (2016b) Effect of hypoxia and hyperoxia on baroreflex sensitivity. In: Computing in coardiology. IEEE, Vancouver, BC, pp 533–536

Zamir M, Badrov MB, Olver TD, Shoemaker JK (2017) Cardiac baroreflex variability and resetting during sustained mild effort. Front Physiol 8:246. doi:10.3389/fphys.2017.00246 CrossRefPubMedPubMedCentral

Zhong X, Hilton HJ, Gates GJ et al (2005) Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. J Appl Physiol Bethesda Md 98:2024–2032. doi:10.1152/japplphysiol.00620.2004 CrossRef

Title: Acute and chronic changes in baroreflex sensitivity in hypobaric vs. normobaric hypoxia
Authors: Nicolas Bourdillon
Jonas Saugy
Laurent Schmitt
Thomas Rupp
Sasan Yazdani
Jean-Marc Vesin
Grégoire P. Millet
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 12/2017
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-017-3726-6

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Acute and chronic changes in baroreflex sensitivity in hypobaric vs. normobaric hypoxia

Abstract

Keynote webinar | Spotlight on sleep in brain health

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