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01-04-2016 | Original Article

Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people

Authors: Ryosuke Shimizu, Kazuki Hotta, Shuhei Yamamoto, Takuya Matsumoto, Kentaro Kamiya, Michitaka Kato, Nobuaki Hamazaki, Daisuke Kamekawa, Ayako Akiyama, Yumi Kamada, Shinya Tanaka, Takashi Masuda

Published in: European Journal of Applied Physiology | Issue 4/2016

Abstract

Purpose

The present study aimed to investigate the effects of low-intensity resistance training with blood flow restriction (BFR resistance training) on vascular endothelial function and peripheral blood circulation.

Methods

Forty healthy elderly volunteers aged 71 ± 4 years were divided into two training groups. Twenty subjects performed BFR resistance training (BFR group), and the remaining 20 performed ordinary resistance training without BFR. Resistance training was performed at 20 % of each estimated one-repetition maximum for 4 weeks. We measured lactate (Lac), norepinephrine (NE), vascular endothelial growth factor (VEGF) and growth hormone (GH) before and after the initial resistance training. The reactive hyperemia index (RHI), von Willebrand factor (vWF) and transcutaneous oxygen pressure in the foot (Foot-tcPO₂) were assessed before and after the 4-week resistance training period.

Results

Lac, NE, VEGF and GH increased significantly from 8.2 ± 3.6 mg/dL, 619.5 ± 243.7 pg/mL, 43.3 ± 15.9 pg/mL and 0.9 ± 0.7 ng/mL to 49.2 ± 16.1 mg/dL, 960.2 ± 373.7 pg/mL, 61.6 ± 19.5 pg/mL and 3.1 ± 1.3 ng/mL, respectively, in the BFR group (each P < 0.01). RHI and Foot-tcPO₂ increased significantly from 1.8 ± 0.2 and 62.4 ± 5.3 mmHg to 2.1 ± 0.3 and 68.9 ± 5.8 mmHg, respectively, in the BFR group (each P < 0.01). VWF decreased significantly from 175.7 ± 20.3 to 156.3 ± 38.1 % in the BFR group (P < 0.05).

Conclusions

BFR resistance training improved vascular endothelial function and peripheral blood circulation in healthy elderly people.

Abdul-Hameed U, Rangra P, Shareef MY, Hussain ME (2012) Reliability of 1-repetition maximum estimation for upper and lower body muscular strength measurement in untrained middle aged type 2 diabetic patients. Asian J Sports Med 3(4):267–273CrossRefPubMedPubMedCentral

Abe T, Kearns CF, Sato Y (2006) Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle. Kaatsu-walk training. J Appl Physiol 100(5):1460–1466. doi:10.1152/japplphysiol.01267.2005 CrossRefPubMed

American College of Sports Medicine position stand (2009) Progression models in resistance training for healthy adults. Med Sci Sports Exerc 41(3):687–708. doi:10.1249/MSS.0b013e3181915670

Breen EC, Johnson EC, Wagner H, Tseng HM, Sung LA, Wagner PD (1996) Angiogenic growth factor mRNA responses in muscle to a single bout of exercise. J Appl Physiol 81(1):355–361PubMed

Conway DS, Pearce LA, Chin BS, Hart RG, Lip GY (2003) Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation. Circulation 107(25):3141–3145. doi:10.1161/01.CIR.0000077912.12202.FC CrossRefPubMed

De Palo EF, Gatti R, Lancerin F, Cappellin E, Spinella P (2001) Correlations of growth hormone (GH) and insulin-like growth factor I (IGF-I): effects of exercise and abuse by athletes. Clin Chim Acta 305(1–2):1–17CrossRefPubMed

de Vos NJ, Singh NA, Ross DA, Stavrinos TM, Orr R, Fiatarone Singh MA (2008) Continuous hemodynamic response to maximal dynamic strength testing in older adults. Arch Phys Med Rehabil 89(2):343–350. doi:10.1016/j.apmr.2007.08.130 CrossRefPubMed

Detmar M (2000) The role of VEGF and thrombospondins in skin angiogenesis. J Dermatol Sci 24(Suppl 1):S78–S84CrossRefPubMed

Downs ME, Hackney KJ, Martin D, Caine TL, Cunningham D, O’Connor DP, Ploutz-Snyder LL (2014) Acute vascular and cardiovascular responses to blood flow-restricted exercise. Med Sci Sports Exerc 46(8):1489–1497. doi:10.1249/MSS.0000000000000253 CrossRefPubMed

Fujita S, Abe T, Drummond MJ, Cadenas JG, Dreyer HC, Sato Y, Volpi E, Rasmussen BB (2007) Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol 103(3):903–910CrossRefPubMed

Gordon SE, Kraemer WJ, Vos NH, Lynch JM, Knuttgen HG (1994) Effect of acid-base balance on the growth hormone response to acute high-intensity cycle exercise. J Appl Physiol 76(2):821–829PubMed

Green DJ, Maiorana A, O’Driscoll G, Taylor R (2004) Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol 561(Pt 1):1–25. doi:10.1113/jphysiol.2004.068197 CrossRefPubMedPubMedCentral

Hoier B, Nordsborg N, Andersen S, Jensen L, Nybo L, Bangsbo J, Hellsten Y (2012) Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol 590(Pt 3):595–606. doi:10.1113/jphysiol.2011.216135 CrossRefPubMedPubMedCentral

Hood JD, Meininger CJ, Ziche M, Granger HJ (1998) VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 274(3 Pt 2):H1054–H1058PubMed

Hunt JE, Walton LA, Ferguson RA (2012) Brachial artery modifications to blood flow-restricted handgrip training and detraining. J Appl Physiol 112(6):956–961. doi:10.1152/japplphysiol.00905.2011 CrossRefPubMed

Ishii H, Uchiyama H, Kazama M (1991) Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemost 65(5):618–623PubMed

Ji JW, Mac Gabhann F, Popel AS (2007) Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise. Am J Physiol 293(6):H3740–H3749. doi:10.1152/ajpheart.00009.2007

Kumahara H, Schutz Y, Ayabe M, Yoshioka M, Yoshitake Y, Shindo M, Ishii K, Tanaka H (2004) The use of uniaxial accelerometry for the assessment of physical-activity-related energy expenditure: a validation study against whole-body indirect calorimetry. Br J Nutr 91(2):235–243. doi:10.1079/BJN20031033 CrossRefPubMed

Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE (2003) Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 146(1):168–174. doi:10.1016/S0002-8703(03)00094-2 CrossRefPubMed

Larkin KA, Macneil RG, Dirain M, Sandesara B, Manini TM, Buford TW (2012) Blood flow restriction enhances post-resistance exercise angiogenic gene expression. Med Sci Sports Exerc 44(11):2077–2083. doi:10.1249/MSS.0b013e3182625928 CrossRefPubMedPubMedCentral

Loenneke JP, Wilson JM, Marin PJ, Zourdos MC, Bemben MG (2012) Low intensity blood flow restriction training: a meta-analysis. Eur J Appl Physiol 112(5):1849–1859. doi:10.1007/s00421-011-2167-x CrossRefPubMed

Matt B (1993) Strength testing—predicting a one-rep max from reps to fatigue. Journal of Physical Education, Recreation and Dance 64(1):88–90CrossRef

McDonagh MJ, Davies CT (1984) Adaptive response of mammalian skeletal muscle to exercise with high loads. Eur J Appl Physiol 52(2):139–155CrossRef

Miyauchi T, Maeda S, Iemitsu M, Kobayashi T, Kumagai Y, Yamaguchi I, Matsuda M (2003) Exercise causes a tissue-specific change of NO production in the kidney and lung. J Appl Physiol 94(1):60–68. doi:10.1152/japplphysiol.00269.2002 CrossRefPubMed

Moritani T, Sherman WM, Shibata M, Matsumoto T, Shinohara M (1992) Oxygen availability and motor unit activity in humans. Eur J Appl Physiol 64(6):552–556CrossRef

Niebauer J, Cooke JP (1996) Cardiovascular effects of exercise: role of endothelial shear stress. JACC 28(7):1652–1660. doi:10.1016/S0735-1097(96)00393-2 CrossRefPubMed

Nohria A, Gerhard-Herman M, Creager MA, Hurley S, Mitra D, Ganz P (2006) Role of nitric oxide in the regulation of digital pulse volume amplitude in humans. J Appl Physiol 101(2):545–548CrossRefPubMed

Ozaki H, Miyachi M, Nakajima T, Abe T (2011) Effects of 10 weeks walk training with leg blood flow reduction on carotid arterial compliance and muscle size in the elderly adults. Angiology 62(1):81–86. doi:10.1177/0003319710375942 CrossRefPubMed

Patterson SD, Leggate M, Nimmo MA, Ferguson RA (2013) Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. Eur J Appl Physiol 113(3):713–719. doi:10.1007/s00421-012-2479-5 CrossRefPubMed

Pollock ML, Carroll JF, Graves JE, Leggett SH, Braith RW, Limacher M, Hagberg JM (1991) Injuries and adherence to walk/jog and resistance training programs in the elderly. Med Sci Sports Exerc 23(10):1194–1200CrossRefPubMed

Pollock ML, Franklin BA, Balady GJ et al (2000) AHA Science Advisory. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription: an advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association; Position paper endorsed by the American College of Sports Medicine. Circulation 101(7):828–833CrossRefPubMed

Rozanski A, Qureshi E, Bauman M, Reed G, Pillar G, Diamond GA (2001) Peripheral arterial responses to treadmill exercise among healthy subjects and atherosclerotic patients. Circulation 103(16):2084–2089CrossRefPubMed

Schechtman KB, Ory MG, Frailty and Injuries: Cooperative Studies of Intervention T (2001) The effects of exercise on the quality of life of frail older adults: a preplanned meta-analysis of the FICSIT trials. Ann Behav Med 23(3):186–197CrossRefPubMed

Shaw CE, McCully KK, Posner JD (1995) Injuries during the one repetition maximum assessment in the elderly. J Cardiopulm Rehabil 15(4):283–287CrossRefPubMed

Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359(6398):843–845. doi:10.1038/359843a0 CrossRefPubMed

Stebbins CL, Longhurst JC (1989) Potentiation of the exercise pressor reflex by muscle ischemia. J Appl Physiol 66(3):1046–1053PubMed

Stewart KJ, Hiatt WR, Regensteiner JG, Hirsch AT (2002) Exercise training for claudication. N Eng J Med 347(24):1941–1951. doi:10.1056/NEJMra021135 CrossRef

Strijdom H, Friedrich SO, Hattingh S, Chamane N, Lochner A (2009) Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes and the role of the PI3-K/PKB pathway. Mol Cell Biochem 321(1–2):23–35. doi:10.1007/s11010-008-9906-2 CrossRefPubMed

Suga T, Okita K, Morita N, Yokota T, Hirabayashi K, Horiuchi M, Takada S, Takahashi T, Omokawa M, Kinugawa S, Tsutsui H (2009) Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. J Appl Physiol 106(4):1119–1124. doi:10.1152/japplphysiol.90368.2008 CrossRefPubMed

Sutton JR, Jones NL, Toews CJ (1976) Growth hormone secretion in acid-base alterations at rest and during exercise. Clin Sci Mol Med 50(4):241–247PubMed

Takano H, Morita T, Iida H, Asada K, Kato M, Uno K, Hirose K, Matsumoto A, Takenaka K, Hirata Y, Eto F, Nagai R, Sato Y, Nakajima T (2005) Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol 95(1):65–73. doi:10.1007/s00421-005-1389-1 CrossRefPubMed

Takarada Y, Nakamura Y, Aruga S, Onda T, Miyazaki S, Ishii N (2000a) Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. J Appl Physiol 88(1):61–65PubMed

Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, Ishii N (2000b) Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. J Appl Physiol 88(6):2097–2106PubMed

Tammela T, Enholm B, Alitalo K, Paavonen K (2005) The biology of vascular endothelial growth factors. Cardiovasc Res 65(3):550–563CrossRefPubMed

Thum T, Tsikas D, Frolich JC, Borlak J (2003) Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line. FEBS Lett 555(3):567–571CrossRefPubMed

Victor RG, Bertocci LA, Pryor SL, Nunnally RL (1988) Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J Clin Invest 82(4):1301–1305. doi:10.1172/JCI113730 CrossRefPubMedPubMedCentral

Vona M, Codeluppi GM, Iannino T, Ferrari E, Bogousslavsky J, von Segesser LK (2009) Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction. Circulation 119(12):1601–1608. doi:10.1161/CIRCULATIONAHA.108.821736 CrossRefPubMed

Wickman A, Jonsdottir IH, Bergstrom G, Hedin L (2002) GH and IGF-I regulate the expression of endothelial nitric oxide synthase (eNOS) in cardiovascular tissues of hypophysectomized female rats. Eur J Eendocrinol 147(4):523–533CrossRef

Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, Bicknell R (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 99(11):2625–2634. doi:10.1172/JCI119451 CrossRefPubMedPubMedCentral

Title: Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people
Authors: Ryosuke Shimizu
Kazuki Hotta
Shuhei Yamamoto
Takuya Matsumoto
Kentaro Kamiya
Michitaka Kato
Nobuaki Hamazaki
Daisuke Kamekawa
Ayako Akiyama
Yumi Kamada
Shinya Tanaka
Takashi Masuda
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 4/2016
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-016-3328-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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